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Titolo:
Retinal ganglion cell genesis requires lakritz, a zebrafish atonal homolog
Autore:
Kay, JN; Finger-Baier, KC; Roeser, T; Staub, W; Baier, H;
Indirizzi:
Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Program Neurosci, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA sci, San Francisco, CA USA Univ Calif San Francisco, Genet Program, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA ram, San Francisco, CA USA Univ Calif San Francisco, Program Human Genet, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA net, San Francisco, CA USA Univ Calif San Francisco, Program Dev Biol, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA iol, San Francisco, CA USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 30, anno: 2001,
pagine: 725 - 736
SICI:
0896-6273(200106)30:3<725:RGCGRL>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRONEURAL GENE; BEHAVIORAL SCREEN; DANIO-RERIO; DIFFERENTIATION; NEUROGENESIS; HEDGEHOG; MATH1; SPECIFICATION; INITIATION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Baier, H Univ Calif San Francisco, Dept Physiol, Box 0444, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0444 San Francisco CA USA 94143 USA
Citazione:
J.N. Kay et al., "Retinal ganglion cell genesis requires lakritz, a zebrafish atonal homolog", NEURON, 30(3), 2001, pp. 725-736

Abstract

Mutation of the zebrafish lakritz (lak) locus completely eliminates the earliest-born retinal cells, the ganglion cells (RGCs). Instead, excess amacrine, bipolar, and Muller glial cells are generated in the mutant. The extraamacrines are found at ectopic locations in the ganglion cell layer. Cone photoreceptors appear unaffected by the mutation. Molecular analysis reveals that lak encodes Ath5, the zebrafish eye-specific ortholog of the Drosophila basic helix-loop-helix transcription factor Atonal. A combined birth-dating and cell marker analysis demonstrates that lak/ath5 is essential for RGC determination during the first wave of neurogenesis in the retina. Our results suggest that this wave is skipped in the mutant, leading to an accumulation of progenitors for inner nuclear layer cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:44:41