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Titolo:
Distinct subpopulations of sensory afferents require F11 or axonin-1 for growth to their target layers within the spinal cord of the chick
Autore:
Perrin, FE; Rathjen, FG; Stoeckli, ET;
Indirizzi:
Univ Basel, Pharmactr, CH-4056 Basel, Switzerland Univ Basel Basel Switzerland CH-4056 armactr, CH-4056 Basel, Switzerland Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany Max Delbruck Ctr Mol Med Berlin Germany D-13092 D-13092 Berlin, Germany
Titolo Testata:
NEURON
fascicolo: 3, volume: 30, anno: 2001,
pagine: 707 - 723
SICI:
0896-6273(200106)30:3<707:DSOSAR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; ROOT GANGLION NEURONS; SEMAPHORIN-III; NG-CAM; COMMISSURAL AXONS; NEURITE OUTGROWTH; NERVOUS-SYSTEM; RECEPTOR GENE; NR-CAM/BRAVO; FLOOR-PLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Stoeckli, ET Univ Basel, Pharmactr, CH-4056 Basel, Switzerland Univ BaselBasel Switzerland CH-4056 056 Basel, Switzerland
Citazione:
F.E. Perrin et al., "Distinct subpopulations of sensory afferents require F11 or axonin-1 for growth to their target layers within the spinal cord of the chick", NEURON, 30(3), 2001, pp. 707-723

Abstract

Dorsal root ganglion neurons project axons to specific target layers in the gray matter of the spinal cord, according to their sensory modality. Using an in vivo approach, we demonstrate an involvement of the two immunoglobulin superfamily cell adhesion molecules axonin-1/TAG-1 and F11/F3/contactinin subpopulation-specific sensory axon guidance. Proprioceptive neurons, which establish connections with motoneurons in the ventral horn, depend on F11 interactions. Nociceptive fibers, which target to layers in the dorsal horn, require axonin-1 for pathfinding. In vitro NgCAM and NrCAM were shownto bind to both axonin-1 and F11. However, despite this fact and despite their ubiquitous expression in the spinal cord, NgCAM and NrCAM are selective binding partners for axonin-1 and F11 in sensory axon guidance. Whereas nociceptive pathfinding depends on NgCAM and axonin-1, proprioceptive fibersrequire NrCAM and F11.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:55:59