Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Methylated cytosine and the brain: A new base for neuroscience
Autore:
Tucker, KL;
Indirizzi:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland Friedrich Miescher Inst Biomed Res Basel Switzerland CH-4058 Switzerland
Titolo Testata:
NEURON
fascicolo: 3, volume: 30, anno: 2001,
pagine: 649 - 652
SICI:
0896-6273(200106)30:3<649:MCATBA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTONE DEACETYLASE COMPLEX; RETT-SYNDROME; DNA METHYLATION; MECP2; MUTATIONS; NEURONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Tucker, KL Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland Friedrich Miescher Inst Biomed Res Basel Switzerland CH-4058
Citazione:
K.L. Tucker, "Methylated cytosine and the brain: A new base for neuroscience", NEURON, 30(3), 2001, pp. 649-652

Abstract

Methylation of genomic CpG residues is crucial for proper neuronal function. Rett syndrome, a common form of mental retardation, is associated with mutations in the gene encoding MeCP2, a methyl CpG binding protein linked totranscriptional repression. Gene knockouts of mouse Mecp2 have reproduced key aspects of the disease. A CNS-restricted knockout of Dnmt1, encoding the enzyme that maintains CpG methylation patterns, results in loss of mutantneurons and glia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 11:08:42