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Titolo:
Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients
Autore:
Dalal, MA; Schuld, A; Haack, M; Uhr, M; Geisler, P; Eisensehr, I; Noachtar, S; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Univ Regensburg, Dept Psychiat, D-8400 Regensburg, Germany Univ Regensburg Regensburg Germany D-8400 at, D-8400 Regensburg, Germany Univ Munich, Dept Neurol, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 h, Dept Neurol, D-8000 Munich, Germany
Titolo Testata:
NEUROLOGY
fascicolo: 12, volume: 56, anno: 2001,
pagine: 1749 - 1751
SICI:
0028-3878(20010626)56:12<1749:NPLOOA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
M.A. Dalal et al., "Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients", NEUROLOGY, 56(12), 2001, pp. 1749-1751

Abstract

Deficient orexin signaling has been shown to cause narcolepsy-like conditions in animals. In human narcolepsy, CSF levels of orexin A (hypocretin-1) were reported to be low in most cases. The authors measured CSF and plasma orexin A levels in patients with narcolepsy and in controls. Confirming earlier studies, they found CSF orexin A levels to be extremely low in patients with narcolepsy. However, plasma orexin A levels did not differ from those observed in controls. These results suggest that orexin deficiency in patients with narcolepsy is a phenomena restricted to the CNS.

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Documento generato il 17/01/20 alle ore 20:41:16