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Titolo:
Comparison of auditory, somatosensory, and visually instructed and internally generated finger movements: A PET study
Autore:
Weeks, RA; Honda, M; Catalan, MJ; Hallett, M;
Indirizzi:
NINDS, Human Motor Control Sect, Med Neurol Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 ed Neurol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NEUROIMAGE
fascicolo: 1, volume: 14, anno: 2001,
parte:, 1
pagine: 219 - 230
SICI:
1053-8119(200107)14:1<219:COASAV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; POSTERIOR CINGULATE CORTEX; EXTERNALLY TRIGGERED MOVEMENTS; SUPPLEMENTARY MOTOR AREA; CEREBRAL BLOOD-FLOW; PREMOTOR CORTEX; FRONTAL-CORTEX; BASAL GANGLIA; NEURONAL-ACTIVITY; CORTICAL AREAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Weeks, RA NINDS, Human Motor Control Sect, Med Neurol Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 Branch, NIH, Bethesda, MD 20892 USA
Citazione:
R.A. Weeks et al., "Comparison of auditory, somatosensory, and visually instructed and internally generated finger movements: A PET study", NEUROIMAGE, 14(1), 2001, pp. 219-230

Abstract

We sought to determine how the pattern of cerebral activation, and in particular in frontal motor areas, during the performance of conditional motor tasks is dependent upon the modality of instruction (visual, auditory, or somatosensory). Regional cerebral blood flow (rCBF) changes with externally instructed movements were also compared with internally generated, self-paced, movements. We used positron emission tomography (PET) with the tracer (H2O)-O-15 to measure rCBF in 22 healthy volunteers, External stimuli consisted of the randomized presentation of single or double impulses using a single modality for each condition. In the movement scans, the subjects used the index and middle fingers of their right hands to press a left button fora single and a right button for a double impulse, respectively. In the control scans, subjects were required to covertly distinguish a single from a double stimulus without a motor response. Data were analyzed using conventional subtraction techniques with a statistical threshold of Z > 2.33 with corrections for multiple comparisons. When the activation differences between the three externally instructed movement conditions were statistically compared, nonsignificant trends toward increased rCBF in the sensory cortex of the modality of the cue were observed but no differential activity in cortical motor areas. Internally generated movements, when compared to externally triggered movements, were associated with enhanced activation in bilateral medial and lateral premotor, dorsolateral prefrontal and superior parietal regions, largely confirming previous reports. The data indicate that, on a regional level, modality-specific processing in a conditional motor task does not occur in frontal motor areas and is probably confined to sensoryareas. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:49:13