Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Measurement of the striatal dopamine transporter density and heterogeneityin type 1 alcoholics using human whole hemisphere autoradiography
Autore:
Tupala, E; Kuikka, JT; Hall, H; Bergstrom, K; Sarkioja, T; Rasanen, P; Mantere, T; Hiltunen, J; Vepsalainen, J; Tiihonen, J;
Indirizzi:
Univ Kuopio, Niuvanniemi Hosp, Dept Forens Psychiat, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Psychiat, FIN-70211 Kuopio, Finland Univ Kuopio, Dept Pharmacol & Toxicol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Toxicol, FIN-70211 Kuopio, Finland Univ Kuopio, Dept Chem, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 ept Chem, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 l Med, SF-70210 Kuopio, Finland Karolinska Hosp & Inst, Dept Clin Neurosci, Psychiat Sect, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden sychiat Sect, Stockholm, Sweden Univ Oulu, Dept Psychiat, Oulu, Finland Univ Oulu Oulu FinlandUniv Oulu, Dept Psychiat, Oulu, Finland MAP Med Technol Ltd, Helsinki, Finland MAP Med Technol Ltd Helsinki Finland Med Technol Ltd, Helsinki, Finland
Titolo Testata:
NEUROIMAGE
fascicolo: 1, volume: 14, anno: 2001,
parte:, 1
pagine: 87 - 94
SICI:
1053-8119(200107)14:1<87:MOTSDT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR-BINDING; HUMAN BRAIN; GENE POLYMORPHISM; FRACTAL ANALYSIS; IOMAZENIL-SPECT; REUPTAKE SITES; ABUSE; RATS; NEUROTRANSMITTER; PERSONALITY;
Keywords:
dopamine; alcoholism; autoradiography; human brain; transporters; binding heterogeneity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Tupala, E Univ Kuopio, Niuvanniemi Hosp, Dept Forens Psychiat, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 FIN-70211 Kuopio, Finland
Citazione:
E. Tupala et al., "Measurement of the striatal dopamine transporter density and heterogeneityin type 1 alcoholics using human whole hemisphere autoradiography", NEUROIMAGE, 14(1), 2001, pp. 87-94

Abstract

Dopaminergic mechanisms are involved in the positive reinforcing and addicting effects of alcohol. Positron emission tomography (PET) and single photon emission tomography (SPET) studies have indicated alterations in striatal dopamine transporters (DAT) and in presynaptic dopamine (DA) function in alcoholics, although also contradictory results have been reported. Normal variations in blood flow, metabolism, and receptor densities are apparentlyimportant to brain function. Such variations are known to decrease during pathophysiological processes, such as epilepsy, whereas normal receptor distributions are broadly heterogenous. We evaluated the densities and heterogeneities of striatal DAT in 8 adult-onset, Cloninger type I alcoholics and 10 controls using [I-128]N-(3-iodoprop-2E-enyl)-2 beta -carbomethoxy-3 beta-(4 '- methylphenyl)nortropane ([I-125]PE2I) as a ligand for human postmortem whole hemisphere autoradiography, which provided high resolution images of the brain when compared with in vivo PET and SPET, The mean density and heterogeneity of DAT were markedly lower in the alcoholics. A significant linear correlation existed between DAT density and heterogeneity, as well asbetween DAT densities in the nucleus accumbens and in the dorsal striatum (caudate and putamen) in alcoholics, but not consistently in controls. The observed low DAT density and heterogeneity in the dorsal striatum suggest that type 1 alcoholics may have a dysfunctional DA system. These data indicate that human whole hemisphere autoradiography with the analysis of bindingheterogeneity may be a relevant tool to measure pathological processes in the brain. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:49:41