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Titolo:
Hypocretin levels in sporadic and familial cases of canine narcolepsy
Autore:
Ripley, B; Fujiki, N; Okura, M; Mignot, E; Nishino, S;
Indirizzi:
Stanford Univ, Sch Med, Ctr Narcolepsy, Stanford Sleep Ctr, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 d Sleep Ctr, Palo Alto, CA 94304 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 3, volume: 8, anno: 2001,
pagine: 525 - 534
SICI:
0969-9961(200106)8:3<525:HLISAF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; OREXIN RECEPTORS; RAT-BRAIN; NEURONS; MODEL; SLEEP; VASOPRESSIN; MECHANISMS; CATAPLEXY; PEPTIDES;
Keywords:
hypocretin; orexin; narcolepsy; CSF; radioimmunoassay; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ripley, B Stanford Univ, Sch Med, Ctr Narcolepsy, Stanford Sleep Ctr, PaloAlto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 r, Palo Alto, CA 94304 USA
Citazione:
B. Ripley et al., "Hypocretin levels in sporadic and familial cases of canine narcolepsy", NEUROBIOL D, 8(3), 2001, pp. 525-534

Abstract

Familial and sporadic forms of narcolepsy exist in both humans and canines. Mutations in the hypocretin receptor 2 gene (Hcrtr 2) cause canine familial narcolepsy. In humans, mutations in hypocretin-related genes are rare, but cerebrospinal fluid (CSF) hypocretin-1 is undetectable in most sporadic cases. Using the canine model, we investigated (1) whether hypocretin deficiency is involved in sporadic cases and (2) whether alterations in hypocretin neurons or ligand levels also contribute to the phenotype in Hcrtr 2 mutants. We found that hypocretins were undetectable in the brains of three ofthree and the CSF of two of two sporadic narcoleptic dogs tested. In contrast, hypocretin levels were not altered in brains and CSF of genetically narcoleptic Dobermans, and hypocretin-containing neurons were of normal appearance. Therefore, multiple hypocretin-related etiologies are likely to be involved in canine narcolepsy. The presence of hypocretin peptides in Hcrtr P-mutated animals suggests that neurotransmission through Hcrtr 1 may be intact, arguing for a preferential importance of Hcrtr 2-mediated function innarcolepsy. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:46:59