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Titolo:
The frissonnant mutant mouse, a model of dopamino-sensitive, inherited motor syndrome
Autore:
Callizot, N; Guenet, JL; Baillet, C; Warter, JM; Poindron, P;
Indirizzi:
Univ Strasbourg 1, Fac Pharm, Lab Pathol Commun Cellules Nerveuses & Mucsulaire, UPRES 2308, F-67401 Illkirch Graffenstaden, France Univ Strasbourg 1 Illkirch Graffenstaden France F-67401 enstaden, France Soc Neurofit SA, F-67400 Illkirch, France Soc Neurofit SA Illkirch France F-67400 fit SA, F-67400 Illkirch, France Inst Pasteur, Unite Genet Mammiferes, F-75724 Paris, France Inst Pasteur Paris France F-75724 enet Mammiferes, F-75724 Paris, France Univ Strasbourg 1, Fac Med, Neurol Clin 2, Serv Maladies Syst Nerveux & Muscle, F-67091 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67091 , F-67091 Strasbourg, France
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 3, volume: 8, anno: 2001,
pagine: 447 - 458
SICI:
0969-9961(200106)8:3<447:TFMMAM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; MICE; NEUROTOXICITY; NEURONS; N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; DEFICITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Poindron, P Univ Strasbourg 1, Fac Pharm, Lab Pathol Commun Cellules Nerveuses & Mucsulaire, UPRES 2308, BP 24, F-67401 Illkirch Graffenstaden, France Univ Strasbourg 1 BP 24 Illkirch Graffenstaden France F-67401
Citazione:
N. Callizot et al., "The frissonnant mutant mouse, a model of dopamino-sensitive, inherited motor syndrome", NEUROBIOL D, 8(3), 2001, pp. 447-458

Abstract

The frissonnant (fri) mutation is an autosomic recessive mutation which spontaneously appeared in the stock of C3H mice. fri mutant mice have locomotor instability and rapid tremor. Since tremor ceases when mutant mice have sleep or are anaesthetized, end because of their obvious stereotyped motor behavior, these mice could represent an inherited Parkinsonian syndrome. Weshow here that the fri/fri mouse fulfills two out of the three criteria required to validate an experimental model of human disease, that is isomorphism, homology and predictivity. Indeed, fri/fri mice present an important motor deficit accompanying visible tremor and stereotypies. They display some memory deficits as in human Parkinson's desease, L-Dopa and apomorphine (dopaminergic agonists), ropinirole (selective D2 agonist), and selegiline (an monoamino-oxidase B [MAO-B] inhibitor) improve their clinical status. However, neither anatomopathological evidence of nigrostriatal lesion, nor decrease in tyrosine hydroxylase production could be seen, (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:20:34