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Titolo:
A synaptic mechanism underlying the behavioral abnormalities induced by manganese intoxication
Autore:
Calabresi, P; Ammassari-Teule, M; Gubellini, P; Sancesario, G; Morello, M; Centonze, D; Marfia, GA; Saulle, E; Passino, E; Picconi, B; Bernardi, G;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 eurol Clin, I-00133 Rome, Italy Osped Santa Lucia, IRCCS, Rome, Italy Osped Santa Lucia Rome ItalyOsped Santa Lucia, IRCCS, Rome, Italy CNR, Ist Psicobiol & Psicofarmacol, I-00198 Rome, Italy CNR Rome Italy I-00198 st Psicobiol & Psicofarmacol, I-00198 Rome, Italy CNR, Ist Med Sperimentale, I-00137 Rome, Italy CNR Rome Italy I-00137CNR, Ist Med Sperimentale, I-00137 Rome, Italy
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 3, volume: 8, anno: 2001,
pagine: 419 - 432
SICI:
0969-9961(200106)8:3<419:ASMUTB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PAIRED-PULSE FACILITATION; PARKINSONS-DISEASE; GLUTAMATERGIC TRANSMISSION; CORTICOSTRIATAL SYNAPSES; NEOSTRIATAL NEURONS; STRIATAL NEURONS; BASAL GANGLIA; D2 RECEPTORS; RAT;
Keywords:
basal ganglia; dopamine receptors; learning; movement disorders; parkinsonism; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Calabresi, P Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Via Tor Vergata135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata135 Rome Italy I-00133
Citazione:
P. Calabresi et al., "A synaptic mechanism underlying the behavioral abnormalities induced by manganese intoxication", NEUROBIOL D, 8(3), 2001, pp. 419-432

Abstract

In the present study we have characterized a rad: model of manganese (Mn) intoxication leading to behavioral disinhibition in the absence of major motor alterations. These behavioral changes were associated with significantly increased brain Mn levels but were uncoupled to anatomical lesions of thestriatum or to morphological and cytochemical changes of the nigrostriataldopaminergic pathway. The analysis of this model at cellular level showed an enhanced dopaminergic inhibitory control of the corticostriatal excitatory transmission via presynaptic DP-like dopamine (DA) receptors in slices obtained from Mn-treated rats. Conversely, the use of agonists acting on presynaptic purinergic, muscarinic, and glutamatergic metabotropic receptors revealed a normal sensitivity. Moreover, membrane responses recorded from single dopaminergic neurons following activation of D2 DA eutoreceptors were also unchanged following Mn intoxication. Thus, our findings indicate a selective involvement of the DP-like DA receptors located on glutamatergic corticostriatal terminals in this pathological condition and suggest that the behavioral symptoms described in the "early" clinical phase of manganism may be caused by an abnormal dopaminergic inhibitory control on corticostriatal inputs. The identification of the synaptic mechanism underlying the "early" phase of Mn intoxication might have a critical importance to understandthe causes of the progression of this pathological condition towards an "established" phase characterized by motor abnormalities and anatomical lesions of the basal ganglia. (C) 2001 Academic Press.

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Documento generato il 20/06/19 alle ore 17:40:25