Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation
Autore:
Morales, JM; Andres, A; Rengel, M; Rodicio, JL;
Indirizzi:
Hosp 12 Octubre, Dept Nephrol, Renal Transplant Unit, E-28041 Madrid, Spain Hosp 12 Octubre Madrid Spain E-28041 nsplant Unit, E-28041 Madrid, Spain Hosp Gen Gregorio Maranon, Dept Nephrol, E-28007 Madrid, Spain Hosp Gen Gregorio Maranon Madrid Spain E-28007 ol, E-28007 Madrid, Spain
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
, volume: 16, anno: 2001, supplemento:, 1
pagine: 121 - 124
SICI:
0931-0509(2001)16:<121:IOCTAR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLOGRAFT REJECTION; FK506; NEPHROTOXICITY; NEPHROPATHY; RECIPIENTS; THERAPY; IMMUNOSUPPRESSION; MULTICENTER; TGF-BETA-1; ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Morales, JM Hosp 12 Octubre, Dept Nephrol, Renal Transplant Unit, Carretera Andalucia Km 5400, E-28041 Madrid, Spain Hosp 12 Octubre Carretera Andalucia Km 5400 Madrid Spain E-28041
Citazione:
J.M. Morales et al., "Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation", NEPH DIAL T, 16, 2001, pp. 121-124

Abstract

Cyclosporin and tacrolimus have improved survival figures in organ transplantation. However, both drugs are potentially nephrotoxic. The immunosuppressive and nephrotoxic effects of both drugs appear to depend on the inhibition of calcineurin. Cyclosporin and tacrolimus cause acute (functional changes) and chronic nephrotoxicity (structural lesions in the kidney). These last important lesions include arteriolar hyalinosis, stripped interstitial fibrosis and tubular atrophy. It is possible that repeated episodes of renal ischaemia contribute to the development of chronic nephrotoxicity and then chronic allograft nephropathy. Cyclosporin and tacrolimus also induce arterial hypertension. Therefore, the beneficial effects of immunosuppression have been limited due to nephrotoxicity and arterial hypertension. Rapamycin, a novel immunosuppressive agent, that does not inhibit calcineurin, provides immunosuppression without nephrotoxicity. In fact, in the trials performed in Europe, sirolimus-treated immunosuppression patients exhibited a much better renal function than cyclosporin-treated patients. However, siroiimus can potentiate the nephrotoxic effect of cyclosporin. Therefore, when cyclosporin and sirolimus are used in combination, a reduction of the cyclosporin dose is desirable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:39:24