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Titolo:
The loop diuretic torasemide interferes with endothelin-1 actions in the aorta of hypertensive rats
Autore:
Fortuno, A; Muniz, P; Zalba, G; Fortuno, MA; Diez, J;
Indirizzi:
Univ Navarra, Fac Med, Sch Med, Div Cardiovasc Pathophysiol, Pamplona 31008, Spain Univ Navarra Pamplona Spain 31008 sc Pathophysiol, Pamplona 31008, Spain
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
, volume: 16, anno: 2001, supplemento:, 1
pagine: 18 - 21
SICI:
0931-0509(2001)16:<18:TLDTIW>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; WISTAR-KYOTO RATS; RESISTANCE ARTERIES; VASCULAR TONE; VASOCONSTRICTION; CHANNEL;
Keywords:
endothelin-l; furosemide; hypertension; torasemide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Diez, J Univ Navarra, Fac Med, Sch Med, Div Cardiovasc Pathophysiol, C Irunlarrea S-N, Pamplona 31008, Spain Univ Navarra C Irunlarrea S-N Pamplona Spain 31008 a 31008, Spain
Citazione:
A. Fortuno et al., "The loop diuretic torasemide interferes with endothelin-1 actions in the aorta of hypertensive rats", NEPH DIAL T, 16, 2001, pp. 18-21

Abstract

Background, The direct effects of torasemide and furosemide ton vasoconstriction and increases in intracellular free calcium concentration ([Ca2+](i)) induced by endothelin-1 (ET-1) were investigated in the aorta of spontaneously hypertensive rats (SHR). Methods, Vascular responses were assessed in endothelium-denuded aortic rings using an organ bath system. Changes of [Ca2+](i) in cultured vascular smooth muscle cells (VSMCs) were assessed using fura-2 methodology. Results. ET-1-induced vasoconstriction was reduced in a dose-dependent wayby torasemide and furosemide (IC50 values: 4.3 +/- 1.4 x 10(-5) and 9.8 +/- 5.6 x 10(-5) M, respectively). The ET-1-induced biphasic [Ca2+](i) increase was blocked by torasemide (IC50 = 2.0 +/- 0.2 x 10(-8) and 2.7 +/- 0.6 x10(-6) M, respectively). Furosemide inhibited the initial rise in [Ca2+](i) induced by ET-1, with no effect on the second rise. The specific chloride(Cl-) channel blocker diphenylamine-2-carboxylate inhibits both ET-1-induced responses in VSMCs (IC50 = 8.0 +/- 0.3 x 10(-9) and 2.5 +/- 0.7 x 10(-7)M, respectively). Conclusions. These results suggest that the ability of loop diuretics to interfere with the vascular actions of ET-1 may involve different molecular mechanisms. The ability of torasemide to block the vasoconstrictive action of ET-1 could include an inhibitory action on Cl- channels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:04:24