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Titolo:
Pathophysiology of cardiovascular damage in the early renal population
Autore:
London, G;
Indirizzi:
Ctr Hosp FH Manhes, Serv Nephrol, F-91700 Fleury Merogis, France Ctr Hosp FH Manhes Fleury Merogis France F-91700 Fleury Merogis, France
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
, volume: 16, anno: 2001, supplemento:, 2
pagine: 3 - 6
SICI:
0931-0509(2001)16:<3:POCDIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTROPHY; FAILURE; DISEASE; ANEMIA;
Keywords:
anaemia; cardiovascular remodelling; left ventricular hypertrophy; renal disease; uraemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: London, G Ctr Hosp FH Manhes, Serv Nephrol, 8 Grnade Rue, F-91700 Fleury Merogis, France Ctr Hosp FH Manhes 8 Grnade Rue Fleury Merogis France F-91700 e
Citazione:
G. London, "Pathophysiology of cardiovascular damage in the early renal population", NEPH DIAL T, 16, 2001, pp. 3-6

Abstract

In renal disease, mechanisms available to compensate for the reduced haemoglobin levels associated with anaemia include increased oxygen extraction from peripheral tissues and, primarily, increased blood flow and changes in blood flow distribution. Haemodynamic changes induced by anaemia include decreases in blood viscosity, peripheral vascular resistance and oxygen delivery, and an increase in sympathetic activity. The overall effect of anaemiais a chronic increase in cardiac output and cardiac work. Under normal conditions, the increased cardiac work and blood flow associated with anaemia results in adaptive left ventricular hypertrophy (LVH)/remodelling and adaptive arterial hypertrophy/remodelling. However, under uraemic conditions these changes lead to maladaptive hypertrophy and arteriosclerosis. In endstage renal disease (ESRD) patients, increases in both left ventricular end-diastolic volume and mass are related to decreases in haemoglobin. Therefore,LVH progresses in parallel with changes in haemoglobin level and is associated with decreased survival in ESRD patients receiving renal replacement therapy. In conclusion, anaemia is a contributory factor to LVH in renal disease and cardiovascular damage starts at an early stage. Therefore, early intervention to treat anaemia in these patients can prevent or delay this damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:22:32