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Titolo:
Effects of a novel, selective, sigma(1)-ligand, MS-377, on phencyclidine-induced behaviour
Autore:
Takahashi, S; Takagi, K; Horikomi, K;
Indirizzi:
Nihon Schering KK, Drug Discovery Inst, Chiba 2970017, Japan Nihon Schering KK Chiba Japan 2970017 scovery Inst, Chiba 2970017, Japan
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 1, volume: 364, anno: 2001,
pagine: 81 - 86
SICI:
0028-1298(200107)364:1<81:EOANSS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGMA-RECEPTOR LIGAND; PIG BRAIN MEMBRANES; LOCOMOTOR STIMULATION; DOPAMINERGIC SYSTEMS; PREPULSE INHIBITION; INDUCED DISRUPTION; NUCLEUS-ACCUMBENS; ACOUSTIC STARTLE; BINDING; RATS;
Keywords:
sigma(1)-ligands; MS-377; NE-100; phencyclidine; rearing; hyperlocomotion; ataxia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, S Nihon Schering KK, Drug Discovery Inst, 1900-1 Togo, Chiba 2970017, Japan Nihon Schering KK 1900-1 Togo Chiba Japan 2970017 017, Japan
Citazione:
S. Takahashi et al., "Effects of a novel, selective, sigma(1)-ligand, MS-377, on phencyclidine-induced behaviour", N-S ARCH PH, 364(1), 2001, pp. 81-86

Abstract

Phencyclidine (PCP)-induced head-weaving is inhibited by a novel selectivesigma (1)-ligand, (R)-(+)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone L-tartrate (MS-377), but not by dopamine D, antagonists. In the present study, we examined the effects of two potent andselective sigma (1)-ligands, MS-377 and N,N-dipropyl-2-(4-methoxy-3-(2-phenyleth ethylamine (NE-100), on PCP-induced rearing behaviour, hyperlocomotion and ataxia in comparison with the currently available antipsychotic agents with affinity for D-2 receptors, haloperidol, sultopride and risperidone. Male Wistar rats or ddY mice were administered MS-377, NE-100, haloperidol, sultopride or risperidone, and PCP was administered 60 min later tin thecase of NE-100 10 min later). Rearing behaviour, hyperlocomotion and ataxia were examined 10 min after PCP administration. MS-377, haloperidol, sultopride and risperidone dose-dependently inhibited PCP-induced rearing and hyperlocomotion, but did not antagonize PCP-induced ataxia. In contrast, the other selective sigma (1)-ligand, NE-100, did not affect any of the PCP-induced behaviour patterns in this study. These results suggest that there areat least two types of ligands for ol-receptors and that some sigma (1)-ligands, including MS-377, have more comprehensive effects against PCP-inducedabnormal behaviour than other sigma (1)-ligands or D-2 antagonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:45:47