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Titolo:
Effects of prolonged oral administration of fumonisin B-1 and aflatoxin B-1 in rats
Autore:
Pozzi, CR; Correa, B; Xavier, JG; Direito, GM; Orsi, RB; Matarazzo, SV;
Indirizzi:
Univ Sao Paulo, ICB, Dept Microbiol, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05508900 BC05508900 Sao Paulo, Brazil Inst Zootecnia, Ctr Nutr & Alimentacao Anim, BR-13460000 Nova Odessa, SP, Brazil Inst Zootecnia Nova Odessa SP Brazil BR-13460000 BCova Odessa, SP, Brazil Univ Estadual Paulista, Inst Ciencias Biomed, Sao Paulo, Brazil Univ Estadual Paulista Sao Paulo Brazil ncias Biomed, Sao Paulo, Brazil
Titolo Testata:
MYCOPATHOLOGIA
fascicolo: 1, volume: 151, anno: 2001,
pagine: 21 - 27
SICI:
0301-486X(2001)151:1<21:EOPOAO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONILIFORME CULTURE MATERIAL; FUSARIUM-MONILIFORME; CORN; TOXICITY; LEUKOENCEPHALOMALACIA; HEPATOTOXICITY; CANCER; CHINA;
Keywords:
aflatoxins; biological effects; fumonisins; prolonged oral; rats Wistar;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Correa, B Univ Sao Paulo, ICB, Dept Microbiol, Av Prof Lineu Prestes 1374,BR-05508900 Sao Paulo, Brazil Univ Sao Paulo Av Prof Lineu Prestes 1374 Sao Paulo Brazil BR-05508900 BC
Citazione:
C.R. Pozzi et al., "Effects of prolonged oral administration of fumonisin B-1 and aflatoxin B-1 in rats", MYCOPATHOLO, 151(1), 2001, pp. 21-27

Abstract

The effects of prolonged oral administration (21 days) of fumonisin B-1 (FB1) and aflatoxin B-1 (AFB(1)) were evaluated on male Wistar rats. The animals were housed in individual metabolic cages and submitted to the following treatments: 1-0 mug AFB(1) + 0 mg FB1/100g bw.; 2-72 mug AFB(1)+ 0 mg FB1/100 g bw; 3-0 mug AFB(1) + 0.5 mg FB1 g bw; 4-0 mug AFB(1) + 1.5 mg FB1/100 g bw; 5-72 mug AFB(1) + 0.5 mg FB1/100g bw; 6-72 mu gAFB(1) + 1.5 mg FB1/100g bw. On day 21, the rats were sacrificed for evaluation. The results showed that treated animals presented differences in body weight and absolute/relative weights of liver and kidney as well as altered hepatic function and cholesterol blood levels. Rats fed with the greatest doses of AFB(1) andFB1 gained less weight (2.79 g/day) at the end of the experimental period;their blood concentrations of liver enzymes aspartate aminotransferase (AST) and alkaline phosphatase (AP) were above control levels (130.35 mu /l and 471.00 mu /l, respectively). Blood cholesterol increased in the groups treated with the highest dose of FB1 or FB1 associated with AFB(1). Histopathology revealed the occurrence of apoptosis in the liver of rats exposed to FB1. The association of aflatoxin B-1 with fumonisin B-1 at higher dose probably potentiated the effects of the higher dose of fumonisin B(1)acting singly.

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Documento generato il 26/01/20 alle ore 10:45:22