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Titolo:
Coupling met to specific pathways results in distinct developmental outcomes
Autore:
Maina, F; Pante, G; Helmbacher, F; Andres, R; Porthin, A; Davies, AM; Ponzetto, C; Klein, R;
Indirizzi:
European Mol Biol Lab, D-69117 Heidelberg, Germany European Mol Biol Lab Heidelberg Germany D-69117 117 Heidelberg, Germany Univ Turin, Dept Anat Pharmacol & Forens Med, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 rmacol & Forens Med, I-10126 Turin, Italy Univ Edinburgh, Royal Dick Sch Vet Studies, Dept Vet Preclin Sci, Edinburgh EH9 1QH, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH9 1QH Midlothian, Scotland
Titolo Testata:
MOLECULAR CELL
fascicolo: 6, volume: 7, anno: 2001,
pagine: 1293 - 1306
SICI:
1097-2765(200106)7:6<1293:CMTSPR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCYTE GROWTH-FACTOR; RECEPTOR TYROSINE KINASES; C-MET; IN-VIVO; ACTIVATION; SIGNAL; GRB2; GAB1; ROLES; TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Maina, F European Mol Biol Lab, Meyerhofstr 1, D-69117 Heidelberg, GermanyEuropean Mol Biol Lab Meyerhofstr 1 Heidelberg Germany D-69117 y
Citazione:
F. Maina et al., "Coupling met to specific pathways results in distinct developmental outcomes", MOL CELL, 7(6), 2001, pp. 1293-1306

Abstract

Receptor tyrosine kinases (RTKs) mediate distinct biological responses by stimulating similar intracellular signaling pathways. Whether the specificity of the response is determined by qualitative or quantitative differencesin signaling output is not known. We addressed this question in vivo by replacing the multifunctional docking sites of Met, the receptor for hepatocyte growth factor, with specific binding motifs for phosphatidylinositol-3 kinase, Src tyrosine kinase, or Grb2 (Met(2P), Met(2S), and Met(2G), respectively). All three mutants retained normal signaling through the multiadaptor Gab1, but differentially recruited specific effecters. While Met2G mice developed normally, Met2P and Met(2S) mice were loss-of-function mutants displaying different phenotypes and rescue of distinct tissues. These data indicate that RTK-mediated activation of specific signaling pathways is required to fulfill cell-specific functions in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:58:40