Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
Autore:
Comijn, J; Berx, G; Vermassen, P; Verschueren, K; van Grunsven, L; Bruyneel, E; Mareel, M; Huylebroeck, D; van Roy, F;
Indirizzi:
State Univ Ghent, VIB, Mol Cell Biol Unit, Dept Biol Mol, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 pt Biol Mol, B-9000 Ghent, Belgium VIB, Dept Cell Growth Differentiat & Dev, B-3000 Louvain, Belgium VIB Louvain Belgium B-3000 h Differentiat & Dev, B-3000 Louvain, Belgium Katholieke Univ Leuven, Lab Mol Biol Celgen, B-3000 Louvain, Belgium Katholieke Univ Leuven Louvain Belgium B-3000 n, B-3000 Louvain, Belgium State Univ Ghent Hosp, Dept Expt Cancerol, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 ncerol, B-9000 Ghent, Belgium
Titolo Testata:
MOLECULAR CELL
fascicolo: 6, volume: 7, anno: 2001,
pagine: 1267 - 1278
SICI:
1097-2765(200106)7:6<1267:TTEBBZ>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY-CARCINOMA CELLS; TRANSCRIPTION FACTOR SNAIL; EPITHELIAL TUMOR-CELLS; GENE-EXPRESSION; BREAST-CANCER; SUPPRESSOR GENE; MAMMALIAN-CELLS; SMAD PROTEINS; DNA-BINDING; REPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: van Roy, F State Univ Ghent, VIB, Mol Cell Biol Unit, Dept Biol Mol, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 , B-9000 Ghent, Belgium
Citazione:
J. Comijn et al., "The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion", MOL CELL, 7(6), 2001, pp. 1267-1278

Abstract

Transcriptional downregulation of E-cadherin appears to be an important event in the progression of various epithelial tumors. SIP1 (ZEB-2) is a Smad-interacting, multi-zinc finger protein that shows specific DNA binding activity. Here, we report that expression of wildtype but not of mutated SIP1 downregulates mammalian E-cadherin transcription via binding to both conserved E2 boxes of the minimal E-cadherin promoter. SIP1 and Snail bind to partly overlapping promoter sequences and showed similar silencing effects. SIP1 can be induced by TGF-P treatment and shows high expression in several E-cadherin-negative human carcinoma cell lines. Conditional expression of SIP1 in E-cadherin-positive MDCK cells abrogates E-cadherin-mediated intercellular adhesion and simultaneously induces invasion. SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:15:53