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Titolo:
Comparative analysis of the expression patterns of Wnts and Frizzleds during early myogenesis in chick embryos
Autore:
Cauthen, CA; Berdougo, E; Sandler, J; Burrus, LW;
Indirizzi:
San Francisco State Univ, Dept Biol, San Francisco, CA 94132 USA San Francisco State Univ San Francisco CA USA 94132 ancisco, CA 94132 USA
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 104, anno: 2001,
pagine: 133 - 138
SICI:
0925-4773(200106)104:1-2<133:CAOTEP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIMB BUD; GENE-EXPRESSION; SONIC-HEDGEHOG; DIFFERENTIAL EXPRESSION; SOMITE SEGMENTATION; PAX-3 EXPRESSION; NERVOUS-SYSTEM; BETA-CATENIN; SPINAL-CORD; NEURAL-TUBE;
Keywords:
chick; dermomyotome; development; embryo; Frizzled; myogenesis; somitogenesis; MyoD; myotome; Myf-5; paraxial mesoderm; segmental plate; sclerotome; skeletal muscle; somite; Sonic Hedgehog; Shh; Wnt;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Burrus, LW San Francisco State Univ, Dept Biol, 1600 Holloway Ave, San Francisco, CA 94132 USA San Francisco State Univ 1600 Holloway Ave San Francisco CA USA 94132
Citazione:
C.A. Cauthen et al., "Comparative analysis of the expression patterns of Wnts and Frizzleds during early myogenesis in chick embryos", MECH DEVEL, 104(1-2), 2001, pp. 133-138

Abstract

During embryogenesis, the transduction of Wnt signals through Frizzled receptors is thought to play integral roles in myogenesis and somite patterning. However, little is known about which Wnt-Frizzled interactions are required for skeletal myogenesis. Thus, we sought to determine which Wnts and Frizzled exhibit expression patterns that are spatiotemporally consistent with the expression of two myogenic determination factors: Myf-5 and MyoD. To accomplish this, we first isolated partial cDNAs for six chick Frizzled orthologues and then compared the expression patterns of chick Frizzleds and Wnts to myogenic and somite patterning factors, such as Myf-5, MyoD, Sonic Hedgehog (Shh), Pax-1 and Pax-3 in Hamburger and Hamilton stage 10 chick. Weused these data to generate a schematic composite of expression patterns at the level of the segmental plate and developing somites (stage V) that shows multiple Frizzled and Witt transcripts expressed in tissues that are overlapping and adjacent to Myf-5 and MyoD expressing tissues. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:57:36