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Titolo:
Rapid three-dimensional diffusion MRI facilitates the study of acute stroke in mice
Autore:
Xue, R; Sawada, M; Goto, S; Hurn, PD; Traystman, RJ; van Zijl, PCM; Mori, S;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Radiol, Div MRI Res, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 MRI Res, Baltimore, MD 21205USA Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 re Med, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 d Engn, Baltimore, MD 21205 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 1, volume: 46, anno: 2001,
pagine: 183 - 188
SICI:
0740-3194(200107)46:1<183:RTDMFT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; DELAYED NEURONAL DEATH; NITRIC-OXIDE SYNTHASE; WATER DIFFUSION; ANISOTROPIC DIFFUSION; ARTERY OCCLUSION; ECHO ACQUISITION; TRANSGENIC MICE; BRAIN WATER; COEFFICIENT;
Keywords:
stroke; vascular occlusion; FSE; diffusion; 3D;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Mori, S Johns Hopkins Univ, Sch Med, Dept Radiol, Div MRI Res, 217 TraylorBldg,720 Rutland Ave, Baltimore, MD 21205 USA Johns Hopkins Univ 217 Traylor Bldg,720 Rutland Ave Baltimore MD USA 21205
Citazione:
R. Xue et al., "Rapid three-dimensional diffusion MRI facilitates the study of acute stroke in mice", MAGN RES M, 46(1), 2001, pp. 183-188

Abstract

MRI studies using mouse brain models of ischemia are becoming a valuable tool for understanding the mechanism of stroke, since transgenic models are now available, However, the small size of the mouse brain and the surgical complexity of creating ischemia in mice make it technically challenging to obtain high-quality MRI data. Therefore, there are few reports of MRI studies in murine cerebral ischemia. In this project a newly developed rapid 3D diffusion-weighted imaging (DWI) technique was applied to study experimental stroke in a mouse model of reversible middle cerebral artery occlusion (MCAO). Ischemic volumes were successfully delineated using this 3D whole-brain imaging technique with high spatial (0.34 x 0.5 x 1.0 mm(3) before zero-filling) and temporal (7 min) resolution, The 3D observation revealed the characteristic evolution of stroke after transient MCAO. There was a temporarily high diffusion constant in the cortex during early reperfusion, followed by a secondary energy failure in the cortex and caudate-putamen at 6 and21 h of reperfusion, Magn Reson Med 46:183-188, 2001. (C) 2001 Wiley-Liss,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 17:47:25