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Titolo:
A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis
Autore:
LaBuda, CJ; Fuchs, PN;
Indirizzi:
Univ Texas, Dept Psychol, Arlington, TX 76019 USA Univ Texas Arlington TXUSA 76019 , Dept Psychol, Arlington, TX 76019 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 4, volume: 69, anno: 2001,
pagine: 443 - 454
SICI:
0024-3205(20010615)69:4<443:ACOCAE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHINE-INDUCED ANALGESIA; ACETYLSALICYLIC-ACID; SWEETENING AGENTS; FORMALIN TEST; BRAIN; MICE; RAT; INVOLVEMENT; REDUCTION; GLUTAMATE;
Keywords:
aspirin; motor activity; arthritis; inflammation; chronic aspartame; exposure; mechanical hyperalgesia; thermal hyperalgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: LaBuda, CJ Univ Texas, Dept Psychol, Box 19528, Arlington, TX 76019 USA Univ Texas Box 19528 Arlington TX USA 76019 ngton, TX 76019 USA
Citazione:
C.J. LaBuda e P.N. Fuchs, "A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis", LIFE SCI, 69(4), 2001, pp. 443-454

Abstract

The purpose of the present study was to investigate whether chronic aspartame exposure possesses analgesic and anti-inflammatory actions in the carrageenan-induced monoarthritis model similar to those properties of aspirin. Prior research demonstrated that aspartame can reduce second phase formalinpain and increase motor activity in arthritic patients. Fifty-eight male Sprague-Dawly rats were treated with aspartame (25, 50, 100 mg/kg) or salinefor six days. An additional group of animals received daily injections of saline and on the sixth treatment day, received a 150-mg/kg dose of aspirin30-minutes prior to behavioral testing. On Day 6, animals received an intra-articular (i.a.) injection of 2% lambda carrageenan (CARR) or an equal volume of saline and were tested four hours later on threshold to mechanical and thermal stimuli, open field activity, and knee joint diameter. Aspirin-treated arthritic animals exhibited significantly less mechanical hyperalgesia and knee joint inflammation compared with vehicle treated arthritic animals. However, aspirin did not reverse thermal hyperalgesia or increase motor activity to control levels. Aspartame did not reduce inflammation, increase motor activity, or attenuate thermal allodynia, but at 50 mg/kg did attenuate mechanical allodynia compared with vehicle treated arthritic animals. The anti-hyperalgesic effect on mechanical hyperalgesia was not seen at 25 mg/kg or 100 mg/kg aspartame. These results suggest that a certain amountof aspartame may provide relief of arthritic pain to a similar degree as aspirin in some individuals. The specific effect of aspartame and aspirin onmechanical hyperalgesia should be considered when these agents are used for the therapeutic treatment of arthritic conditions. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:47:53