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Titolo:
A discriminative two-lever test of dizocilpine's ability to reinstate ethanol-seeking behavior
Autore:
Vosler, PS; Bombace, JC; Kosten, TA;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 , Dept Psychiat, New Haven, CT 06508 USA Quinnipiac Univ, Dept Psychol, Hamden, CT USA Quinnipiac Univ Hamden CT USA nnipiac Univ, Dept Psychol, Hamden, CT USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 5, volume: 69, anno: 2001,
pagine: 591 - 598
SICI:
0024-3205(20010622)69:5<591:ADTTOD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-SEEKING; RATS; NALTREXONE; STRESS; SUBSTITUTION; ANTAGONISTS; EXTINCTION; INHIBITION; DEPENDENCE; STIMULI;
Keywords:
alcohol self-administration; relapse; NMDA antagonist; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kosten, TA Yale Univ, Sch Med, Dept Psychiat, Room S-305 CMHC,34 Pk St, New Haven, CT06508 USA Yale Univ Room S-305 CMHC,34 Pk St New Haven CT USA 06508 8 USA
Citazione:
P.S. Vosler et al., "A discriminative two-lever test of dizocilpine's ability to reinstate ethanol-seeking behavior", LIFE SCI, 69(5), 2001, pp. 591-598

Abstract

Because ethanol has N-methyl-D-aspartate (NMDA) antagonist effects, we tested whether dizocilpine, an NMDA antagonist, reinstates ethanol-seeking behavior. Rats were trained to lever-press for a 10% ethanol/2% sucrose (EtOH)or a 3% sucrose (Suc) solution using a two-lever tone lever active) procedure (FR2). After extinction, rats were injected with ethanol (0.5 g/kg). The EtOH group emitted more active than inactive lever presses and the Suc group showed minimal responding. Thus, ethanol reinstated ethanol-seeking behavior in a specific manner. In contrast, dizocilpine (0.175 mg/kg) increased responding on both levers in both groups suggesting a loss of discriminative control. Dizocilpine fails to reinstate ethanol-seeking behavior. Thesedata also demonstrate the necessity of using a discriminative, two-lever test for drug reinstatement. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 18/01/20 alle ore 13:59:06