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Titolo:
Szygium aromaticum (L.) Merr. Et Perry (Myrtaceae) flower bud induces apoptosis of p815 mastocytoma cell line
Autore:
Park, HI; Jeong, MH; Lim, YJ; Park, BS; Kim, GC; Lee, YM; Kim, HM; Yoo, KS; Yoo, YH;
Indirizzi:
Dong A Univ, Coll Med, Dept Anat & Cell Biol, Pusan 602714, South Korea Dong A Univ Pusan South Korea 602714 ell Biol, Pusan 602714, South Korea Inst Med Sci, Pusan, South Korea Inst Med Sci Pusan South KoreaInst Med Sci, Pusan, South Korea Dong A Univ, Coll Med, Dept Microbiol & Immunol, Pusan, South Korea Dong AUniv Pusan South Korea t Microbiol & Immunol, Pusan, South Korea Dong A Univ, Coll Med, Dept Parasitol, Pusan, South Korea Dong A Univ Pusan South Korea l Med, Dept Parasitol, Pusan, South Korea Pusan Natl Univ, Coll Dent, Dept Oral Anat & Cell Biol, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 Biol, Pusan 609735, South Korea Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea arm, Iksan, Chonbuk, South Korea
Titolo Testata:
LIFE SCIENCES
fascicolo: 5, volume: 69, anno: 2001,
pagine: 553 - 566
SICI:
0024-3205(20010622)69:5<553:SA(MEP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C RELEASE; MAST-CELLS; BCL-2; DEATH; METHYLEUGENOL; MITOCHONDRIA; EXPRESSION; PROTEASES; PATHWAYS; EUGENOL;
Keywords:
apoptosis; mast cell; cloves; caspase; mitochondria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Yoo, YH Dong A Univ, Coll Med, Dept Anat & Cell Biol, 3-1 Dongdaesin Dong,Pusan 602714, South Korea Dong A Univ 3-1 Dongdaesin Dong Pusan South Korea 602714 th Korea
Citazione:
H.I. Park et al., "Szygium aromaticum (L.) Merr. Et Perry (Myrtaceae) flower bud induces apoptosis of p815 mastocytoma cell line", LIFE SCI, 69(5), 2001, pp. 553-566

Abstract

This study was conducted to investigate SAFE-induced apoptosis of mast cells as it pertains to both its basic drug mechanism and the potential therapeutics of the pathologic conditions accompanying mast cell proliferation. SAFE induced many apoptotic manifestations as evidenced by changes in cell morphology, generation of DNA fragmentation, activation of caspase 3, and DNA hypoploidy. The reduction of mitochondrial membrane potential and the release of cytochrome c to cytosol were also demonstrated. However, reduction of mitochondrial membrane potential and cytochrome c release were not prevented by caspase inhibitor zVAD-fmk or PTP blockers such as bongkrekic acid and cyclosporin A. Expression levels of Bcl-2 and Fas remained unchanged following SAFE treatment. This results suggest that the clinical effect of SAFE may depend on the pharmacological mechanism regulating the demise of mast cells. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:18:13