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Titolo:
Properties of self-assembled aggregates of fluoroalkyl end-capped oligomers
Autore:
Sawada, H; Kawase, T;
Indirizzi:
Nara Natl Coll Technol, Dept Chem, Nara 6391080, Japan Nara Natl Coll Technol Nara Japan 6391080 Dept Chem, Nara 6391080, Japan Osaka City Univ, Fac Human Life Sci, Osaka 5588585, Japan Osaka City UnivOsaka Japan 5588585 Human Life Sci, Osaka 5588585, Japan
Titolo Testata:
KOBUNSHI RONBUNSHU
fascicolo: 6, volume: 58, anno: 2001,
pagine: 255 - 266
SICI:
0386-2186(2001)58:6<255:POSAOF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
JPN
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; 4-VINYLPYRIDINIUM CHLORIDE OLIGOMERS; CROSS-LINKED CONDITIONS; ACID CO-OLIGOMERS; SURFACTANT PROPERTIES; HYDROXY SEGMENTS; BINDING; INHIBITORS; PEROXIDES; GELATION;
Keywords:
aggregate; anti-HIV-1 activity; antibacterial activity; metal ion-binding; molecular recognition; immobilized enzyme; chemiluminescence; fluorinated polymer drug;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Sawada, H Nara Natl Coll Technol, Dept Chem, Nara 6391080, Japan Nara NatlColl Technol Nara Japan 6391080 Nara 6391080, Japan
Citazione:
H. Sawada e T. Kawase, "Properties of self-assembled aggregates of fluoroalkyl end-capped oligomers", KOBUNSH RON, 58(6), 2001, pp. 255-266

Abstract

The molecular assemblies formed in aqueous solutions of fluoroalkyl end-capped acrylic acid and sulfonic acid oligomers were able to interact with HIV-I virus leading to more potent inhibitory effects against HIV-I replication. In fluoroalkyl end-capped oligomers containing cationic segments, theseoligomers were clarified to exhibit not only a good surfactant property imparted by fluorine but also an antibacterial activity. A variety of fluoroalkyl end-capped oligomers containing amido segments can easily form the molecular aggregates in water, and calcium ions were found to act as guest molecules for these fluorinated aggregates. In particular, self-assembled aggregates of fluoroalkyl end-capped N-(1,1-dimethyl-3-oxobutyl) acrylamide oligomers can recognize selectively hydrophilic amino and N,N-dimethylamino compounds. Luminol was also clarified to become a potential guest molecule for these fluorinated molecular aggregates to enhance chemiluminescence intensity. Moreover, these fluorinated aggregates selectively immobilize cytochrome c, and immobilized cytochrome c retains its catalytic activity for oxidation of guaiacol with hydrogen peroxide. A fluoroalkanoyl peroxide was also demonstrated to become a convenient tool for the preparation of novel water-soluble fluoroalkyl end-capped cooligomer-bound antitumor agents such as5-fluorouracil. and this cooligomer had a remarkably strong interaction with DNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:24:19