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Titolo:
Post-transplant renal artery stenosis: The hemodynamic response to revascularization
Autore:
Ruggenenti, P; Mosconi, L; Bruno, S; Remuzzi, A; Sangalli, F; Lepre, MS; Agazzi, R; Nani, R; Fasolini, G; Remuzzi, G;
Indirizzi:
Mario Negri Inst Pharmacol Res, Clin Res Ctr Rare Dis Aldo & Cele Dacco, I-24125 Bergamo, Italy Mario Negri Inst Pharmacol Res Bergamo Italy I-24125 4125 Bergamo, Italy Osped Riuniti Bergamo, Azienda Osped, Unit Nephrol, Bergamo, Italy Osped Riuniti Bergamo Bergamo Italy Osped, Unit Nephrol, Bergamo, Italy Osped Riuniti Bergamo, Azienda Osped, Radiol Unit, Bergamo, Italy Osped Riuniti Bergamo Bergamo Italy Osped, Radiol Unit, Bergamo, Italy
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 1, volume: 60, anno: 2001,
pagine: 309 - 318
SICI:
0085-2538(200107)60:1<309:PRASTH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR SIZE-SELECTIVITY; CAPILLARY WALL; NEUTRAL DEXTRAN; PERMSELECTIVITY; MACROMOLECULES; HYPERTENSION; DYNAMICS; HUMANS; RENIN; RATS;
Keywords:
stenosis; transplantation; vascula perfusion; Doppler ultrasound; hypertension; kidney perfusion; renal artery stenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ruggenenti, P Mario Negri Inst Pharmacol Res, Clin Res Ctr Rare Dis Aldo &Cele Dacco, Via Gavazzeni 11, I-24125 Bergamo, Italy Mario Negri Inst Pharmacol Res Via Gavazzeni 11 Bergamo Italy I-24125
Citazione:
P. Ruggenenti et al., "Post-transplant renal artery stenosis: The hemodynamic response to revascularization", KIDNEY INT, 60(1), 2001, pp. 309-318

Abstract

Background. Percutaneous transluminal angioplasty and stenting are relatively noninvasive approaches to treat posttransplant renal artery stenosis. However. the real impact of this procedure on renal function recovery has never been quantitated precisely to date. Methods. In eight consecutive renal transplant patients with renal graft artery stenosis, blood pressure, body weight, and anatomical, functional, and Doppler ultrasound parameters were evaluated before and one month after renal artery transluminal angioplasty and stenting. On both occasions, glomerular filtration rate and renal plasma flow were evaluated by inulin and paraaminohippuric acid renal clearances, and glomerular size-selective function was evaluated by the fractional clearances of neutral dextran macromolecules. Results. The correction of renal artery stenosis, by normalizing renal vascular resistances, fully restored kidney perfusion and decreased arterial blood pressure. relieved water and sodium retention, restored an almost laminar arterial blood flow, and normalized vascular shear stress without appreciable effects on glomerular barrier size-selective function and proteinuria. Preangioplasty and postangioplasty renal resistive indices and peak systolic blood velocity estimated by Doppler ultrasounds were significantly correlated with the effective renal plasma how and the blood velocity calculated at the site of stenosis. All patients were discharged without sequelae one or two days after angioplasty. Conclusions. Percutaneous transluminal angioplasty and stenting are safe and effective procedures to normalize the functional changes sustained by hemodynamically significant artery stenosis after renal transplantation. Doppler ultrasound scanning is a reliable and reproducible technique to monitorthe renal functional response to vascular reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 22:20:29