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Titolo:
Frequency of renal phosphate leak among patients with calcium nephrolithiasis
Autore:
Prie, D; Ravery, V; Boccon-Gibod, L; Friedlander, G;
Indirizzi:
Hop Bichat, Dept Physiol Explorat Fonctionnelles, F-78018 Paris, France Hop Bichat Paris France F-78018 at Fonctionnelles, F-78018 Paris, France Hop Bichat, Dept Urol, F-78018 Paris, France Hop Bichat Paris France F-78018 Bichat, Dept Urol, F-78018 Paris, France
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 1, volume: 60, anno: 2001,
pagine: 272 - 276
SICI:
0085-2538(200107)60:1<272:FORPLA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEREDITARY HYPOPHOSPHATEMIC RICKETS; IDIOPATHIC HYPERCALCIURIA; STONE FORMATION; PHOSPHORUS; 1,25-DIHYDROXYVITAMIN-D; EXCRETION; THRESHOLD; LOCUS;
Keywords:
stone formers; lithiasis; renal stones; hypercalciuria; hyperphosphaturia; urinary calcium excretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Prie, D Hop Bichat, Dept Physiol Explorat Fonctionnelles, 48 Rue Henri Huchard, F-78018 Paris, France Hop Bichat 48 Rue Henri Huchard Paris France F-78018 aris, France
Citazione:
D. Prie et al., "Frequency of renal phosphate leak among patients with calcium nephrolithiasis", KIDNEY INT, 60(1), 2001, pp. 272-276

Abstract

Background. Nephrolithiasis is a frequent disorder affecting 10 to 15% of the population in Europe and the United States. More than 80% of renal stones are made of calcium oxalate and calcium phosphate. The main identified risks for calcium renal stone formation are hypercalciuria and urinary saturation. A urine phosphate (Pi) loss is often associated with hypercalciuria;furthermore, hyperphosphaturia increases urinary saturation. Methods. To determine whether urinary phosphate loss is associated with calcium urolithiasis. we measured renal Pi threshold (TmPi) in 207 stent: formers with normal parathyroid hormone (PTH) serum concentration and in 105 control subjects. Results. The TmPi followed a normal distribution in both groups. The mean TmPi was significantly lower in stone formers versus controls (0.72 +/- 0.13 vs. 0.87 +/- 0.18 mmol/L, P < 0.0001) because of a shift to the left of the TmPi distribution curve in the stone former population, with no evidencefor bimodal distribution. Five percent of the controls had a TmPi < 0.63 versus 19% of the stone formers. Daily urinary calcium excretion was significantly higher in stone formers than in controls. Calcium excretion was alsosignificantly higher in stone formers with TmPi < 0.63 mmol/L compared with those with TmPi greater than or equal to0.63. Serum PTH and ionized calcium concentrations were not different in stone formers and in control subjects, whatever the TmPi value. Conclusions. A low TmPi is more frequently encountered in stone formers with a normal PTH concentration than in control subjects and is associated with a high urinary Ca excretion. The hypophosphatemia induced by a renal phosphate leak may predispose the subject to calcium stone formation by increasing the serum calcitriol level, calcium excretion, and urinary saturation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:27:57