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Titolo:
Angiogenesis in autosomal-dominant polycystic kidney disease
Autore:
Bello-Reuss, E; Holubec, K; Rajarman, S;
Indirizzi:
Univ Texas, Med Branch, Div Nephrol, Dept Internal Med, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 t Internal Med, Galveston, TX 77555 USA Univ Texas, Med Branch, Dept Physiol & Biophys, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 siol & Biophys, Galveston, TX 77555 USA Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 h, Dept Pathol, Galveston, TX 77555 USA
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 1, volume: 60, anno: 2001,
pagine: 37 - 45
SICI:
0085-2538(200107)60:1<37:AIAPKD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY FACTOR; ENDOTHELIAL GROWTH-FACTOR; VESSEL DEVELOPMENT; PHVEGF(165); ISCHEMIA; THERAPY; CELLS;
Keywords:
vascular endothelial growth factor; inherited kidney disease; cysts; genetic disorder; progressive renal disease; KDR; MMP-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Bello-Reuss, E Univ Texas, Med Branch, Div Nephrol, Dept Internal Med, Room 4-200,John Sealy Annex,301 Univ Blvd, Galveston, TX 77555 USA Univ Texas Room 4-200,John Sealy Annex,301 Univ Blvd Galveston TX USA 77555
Citazione:
E. Bello-Reuss et al., "Angiogenesis in autosomal-dominant polycystic kidney disease", KIDNEY INT, 60(1), 2001, pp. 37-45

Abstract

Background. Autosomal-dominant polycystic kidney disease (ADPKD) is a genetic disorder that is responsible for approximately 10% of all cases of end-stage renal disease (ESRD). It is characterized by the formation of epithelial cell cysts, an increase in the extracellullar matrix. and vascular alterations believed to be the result of compression by the cysts. Our recent observations demonstrated a rich vascular network on the surface of the cysts, and thus, we postulated that angiogenesis could be a factor in the progression of ADPKD. Methods. Kidneys removed from patients with ADPKD were studied using (1) angiographs, (2) immunostaining [factor VIII-related antigen, vascular endothelial growth factor (VEGF), VEGF receptors 1 and 2 (VEGFR-1 and VEGFR-2), metallo-proteinase-2 (MMP-2), and integrin alpha (v)beta (3) and (3) Western blot analysis and enzyme-linked immunosorbent assay. The expression of VEGF(165) in ADPKD cells in culture was determined. Results. There was (1) an extensive capillary network in the cyst wall of ADPKD kidneys. (2) morphological evidence of vascular malformations, (3) expression of VEGF(165) in cyst cells of VEGFR-2 in endothelial cells and an absence of VEGFR-1 in endothelial cells, (4) secretion of VEGF(165) by ADPKD cyst cells in culture, and (5) coexpression of matrix MMP-2 and integrin alpha (v)beta (3) in vessels from ADPKD. Conclusions. There is angiogenesis in ADPKD. This process may be necessaryfor cyst cells to grow and may be responsible for increased vascular permeability facilitating fluid secretion into the cysts. Neovascularization mayresult in the formation of aneurysms responsible for the renal bleeding inthis disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:58:31