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Titolo:
Organotins disrupt components of glutamate homeostasis in rat astrocyte cultures
Autore:
Karpiak, VC; Bridges, RJ; Eyer, CL;
Indirizzi:
Univ Montana, Sch Pharm & Allied Hlth Sci, Dept Pharmaceut Sci, Missoula, MT 59812 USA Univ Montana Missoula MT USA 59812 Pharmaceut Sci, Missoula, MT 59812 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 4, volume: 63, anno: 2001,
pagine: 273 - 287
SICI:
1528-7394(20010622)63:4<273:ODCOGH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM; D-ASPARTATE; TRIMETHYLTIN; SYNTHETASE; INHIBITION; BRAIN; NEUROTOXICITY; TRIETHYLTIN; TRANSPORT; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Eyer, CL Univ Montana, Sch Pharm & Allied Hlth Sci, Dept Pharmaceut Sci, Missoula, MT 59812 USA Univ Montana Missoula MT USA 59812 t Sci, Missoula, MT 59812 USA
Citazione:
V.C. Karpiak et al., "Organotins disrupt components of glutamate homeostasis in rat astrocyte cultures", J TOX E H A, 63(4), 2001, pp. 273-287

Abstract

Arat cortical astrocyte preparation was used to investigate the effects oforganotins on glutamate regulation by astrocytes. Exposure of astrocytes to low levels of organotins produced significant changes in two key components of glutamate homeostasis: glutamine synthetase (GS) activity and the high-affinity transport of L-glutamate. Trimethyltin (TMT), triethyltin (TET),and triphenyltin (TPT) exhibited differential abilities to reduce GS activity and glutamate uptake. Cultures incubated with 1 muM TET or TPT, but notTMT, exhibited a marked decrease in GS activity. Exposure to TET or TPT also produced a significant decrease in glutamate transport activity that wasnot observed with TMT. These declines in activity were not attributable tocell loss as measured by MTT reduction and lactate dehydrogenase (LDH) leakage. Since the loss of GS activity and transporter activity was not seen with acute organotin exposure, it is most likely attributable to a decreasedpresence of fully functioning protein. While the attenuation of GS and glutamate transporter activities by organotins does not match their pattern ofneurotoxicity, the results indicate the potential for subtoxic concentrations of these compounds to increase extracellular glutamate and interact with other excitotoxic episodes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:20:02