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Titolo:
Combined exposure to DEET (N,N-diethyl-m-toluamide) and permethrin-inducedrelease of rat brain mitochondrial cytochrome c
Autore:
Abu-Qare, AW; Abou-Donia, MB;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 4, volume: 63, anno: 2001,
pagine: 243 - 252
SICI:
1528-7394(20010622)63:4<243:CETD(A>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE CELLS; CASPASE ACTIVATION; INDUCED APOPTOSIS; INSECT REPELLENTS; GULF-WAR; PYRIDOSTIGMINE BROMIDE; TOXIC ENCEPHALOPATHY; CARCINOMA-CELLS; DNA-DAMAGE; DEPOLARIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Abou-Donia, MB Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 c Biol, Durham, NC 27710 USA
Citazione:
A.W. Abu-Qare e M.B. Abou-Donia, "Combined exposure to DEET (N,N-diethyl-m-toluamide) and permethrin-inducedrelease of rat brain mitochondrial cytochrome c", J TOX E H A, 63(4), 2001, pp. 243-252

Abstract

The release of cytochrome c from the mitochondrial intermembrane space caninduce apoptosis. The levels of mitochondrial cytochrome c in rat brain following a single dermal dose of 400 mg/kg of DEET, and of 1.3 mg/kg of permethrin, alone or in combination were determined. Rats were sacrificed at a time interval of 0.5, 1, 2, 4, 8, 16, 24, 48, or 72 h after dosing. Brain mitochondria were isolated and the levels of cytochrome c were measured using reversed-phase high-performance liquid chromatography ( HPLC) with ultraviolet ( UV) detection. Average percentage recovery of cytochrome c spiked with control rat brain mitochondria was 83.2 +/-8.9%. Limits of detection and quantitation were 1 and 5 ng, respectively. The results showed that a single dermal dose of a combination of DEET and permethrin significantly increased the release of brain mitochondrial cytochrome c starting 24 h after treatment. DEET and permethrin alone did not affect the release of cytochromec. The results indicate that combined exposure to DEET and permethrin might induce the apoptotic processes in rat brain as seen by the release of cytochrome c.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 13:38:04