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Titolo:
MODULATION OF EXCITATORY SYNAPTIC TRANSMISSION IN LOCUS-COERULEUS BY MULTIPLE PRESYNAPTIC METABOTROPIC GLUTAMATE RECEPTORS
Autore:
DUBE GR; MARSHALL KC;
Indirizzi:
UNIV OTTAWA,FAC MED,DEPT PHYSIOL OTTAWA ON K1H 8M5 CANADA UNIV OTTAWA,FAC MED,DEPT PHYSIOL OTTAWA ON K1H 8M5 CANADA
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 80, anno: 1997,
pagine: 511 - 521
SICI:
0306-4522(1997)80:2<511:MOESTI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; NEONATAL RAT HIPPOCAMPUS; PHENYLGLYCINE DERIVATIVES; CALCIUM CHANNELS; CERULEUS NEURONS; NUCLEUS PARAGIGANTOCELLULARIS; MOLECULAR CHARACTERIZATION; IONOTROPIC GLUTAMATE; SIGNAL-TRANSDUCTION; PYRAMIDAL CELLS;
Keywords:
METABOTROPIC GLUTAMATE RECEPTOR; PRESYNAPTIC; LOCUS COERULEUS; EXCITATORY POSTSYNAPTIC POTENTIALS; L-AP4; T-ACPD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Dube e K.C. Marshall, "MODULATION OF EXCITATORY SYNAPTIC TRANSMISSION IN LOCUS-COERULEUS BY MULTIPLE PRESYNAPTIC METABOTROPIC GLUTAMATE RECEPTORS", Neuroscience, 80(2), 1997, pp. 511-521

Abstract

Metabotropic glutamate receptors have been implicated in modulation of synaptic transmission in many different systems. This study reports the effects of selective activation of metabotropic glutamate receptors on synaptic transmission in intracellularly recorded locus coeruleusneurons in brain slice preparations. Perfusion of either L-2-amino-4-phosphonobutyric acid (L-AP4; 0.1-500 mu M) or (+/-)-1-aminocyclopentane-trans-1,3,dicarboxylic acid (t-ACPD; 0.1-500 mu M) caused a depression of excitatory postsynaptic potentials in a dose-dependent fashion to about 70% inhibition. Both agonists exerted their effects at relatively low concentrations with estimated EC(50)s of 2.6 mu M and 11.5; mu M for L-AP4 and t-ACPD, respectively. This inhibition was not observed with the potent, group I metabotropic glutamate receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG; 100 mu M). Conversely, (R)-4-carboxy-3-hydroxyphenyl-glycine (4C-3H-PG), a group I antagonist/group II agonist, and 2R,4R-4-amino-pyrrolidine-2,4-dicarboxylate (APDC), a novel and specific group II agonist, also caused an inhibit ion of excitatory postsynaptic potentials. Both t-ACPD and L-AP4 produced an increase in paired-pulse facilitation. and Failed to change the locus coeruleus response to focally applied glutamate, indicating a presynaptic locus of action. The L-AP4 inhibition was antagonized by (S)-amino-2-methyl-4-phosphonobutanoic acid (MAP4; group III antagonist) but not by (RS)-alpha-methyl-4-carboxyphenylglycine [(RS)-MCPG; mixed antagonist],suggesting that this agonist acts through a type 4 metabotropic glutamate receptor. Conversely, t-ACPD was antagonized by MCPG and by ethylglutamate (group II antagonist). but not by aminoindan dicarboxylic acid (AIDA; group I antagonist) or MAP4, suggesting that this agonist acts on a type 2 or 3 metabotropic glutamate receptor.Taken together, these results suggest that two pharmacologically distinct presynaptic metabotropic glutamate receptors function in an additive fashion to inhibit excitatory synaptic transmission in locus coeruleus neurons. These receptors may be involved in a feedback mechanism and as such may function as autoreceptors for excitatory amino acids. (C) 1997 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 21/09/20 alle ore 12:54:57