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Titolo:
Cardiac natriuretic peptides are related to left ventricular mass and function and predict mortality in dialysis patients
Autore:
Zoccali, C; Mallamaci, F; Benedetto, FA; Tripepi, G; Parlongo, S; Cataliotti, A; Cutrupi, S; Giacone, G; Bellanuova, I; Cottini, E; Malatino, LS;
Indirizzi:
CNR, Ctr Fisiol Clin, I-89100 Reggio Calabria, Italy CNR Reggio CalabriaItaly I-89100 l Clin, I-89100 Reggio Calabria, Italy Osped Morelli, Div Nefrol, Reggio Calabria, Italy Osped Morelli Reggio Calabria Italy Div Nefrol, Reggio Calabria, Italy Osped Morelli, Serv Cardiol, Reggio Calabria, Italy Osped Morelli Reggio Calabria Italy erv Cardiol, Reggio Calabria, Italy Univ Catania, Ist Clin Med L Condorelli, Catania, Italy Univ Catania Catania Italy a, Ist Clin Med L Condorelli, Catania, Italy
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 7, volume: 12, anno: 2001,
pagine: 1508 - 1515
SICI:
1046-6673(200107)12:7<1508:CNPART>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; HEMODIALYSIS-PATIENTS; MYOCARDIAL-INFARCTION; PLASMA-CONCENTRATION; HEART-FAILURE; BRAIN; HYPERTROPHY; HYPERTENSION; INDICATOR; GEOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Zoccali, C CNR, Ctr Fisiol Clin, Via Sbarre Inferiori 39, I-89100 Reggio Calabria, Italy CNR Via Sbarre Inferiori 39 Reggio Calabria Italy I-89100 taly
Citazione:
C. Zoccali et al., "Cardiac natriuretic peptides are related to left ventricular mass and function and predict mortality in dialysis patients", J AM S NEPH, 12(7), 2001, pp. 1508-1515

Abstract

This study was designed to investigate the relationship among brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) and left ventricular mass (LVM), ejection fraction, and LV geometry in a large cohort of dialysis patients without heart failure (n = 246) and to test the prediction power of these peptides for total and cardiovascular mortality. In separate multivariate models of LVM, BNP and ANP were the strongest independent correlates of the LVM index. In these models, the predictive power of BNP was slightly stronger than that of ANP. Both natriuretic peptides also were the strongest independent predictors of ejection fraction, and again BNP was a slightly better predictor of ejection fraction than ANP. In separate multivariate Cox models, the relative risk of death was significantly higher in patients of the third tertile of the distribution of BNP and ANP than in those of the first tertile (BNP, 7.14 [95% confidence interval (CI), 2.83 to 18.01, P = 0.00001]; ANP, 4.22 [95% CI, 1.79 to 9.92, P = 0.001]), and a similar difference was found for cardiovascular death (BNP, 6.72 [95% CI, 2.44 to 18.54, P = 0.0002]; ANP, 3.80 [95% CI, 1.44 to 10.03, P = 0.007]). BNP but not ANP remained as an independent predictor of death in a Cox's model including LVM and ejection fraction. Cardiac natriuretic peptides are linkedindependently to LVM and function in dialysis patients and predict overalland cardiovascular mortality. The measurement of the plasma concentration of BNP and ANP may be useful for risk stratification in these patients.

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Documento generato il 26/01/21 alle ore 04:45:36