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Titolo:
Dissociation reactions of gaseous ferro-, ferri-, and apo-cytochrome c ions
Autore:
Wells, JM; Reid, GE; Engel, BJ; Pan, P; McLuckey, SA;
Indirizzi:
Purdue Univ, Dept Chem, Brown Labs 1393, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 Labs 1393, W Lafayette, IN 47907 USA
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
fascicolo: 7, volume: 12, anno: 2001,
pagine: 873 - 876
SICI:
1044-0305(200107)12:7<873:DROGFF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESOLUTION MASS-SPECTROMETRY; ELECTROSPRAY IONIZATION; TRAP; HEMOGLOBIN; PROTEINS; CATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: McLuckey, SA Purdue Univ, Dept Chem, Brown Labs 1393, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 Lafayette, IN 47907 USA
Citazione:
J.M. Wells et al., "Dissociation reactions of gaseous ferro-, ferri-, and apo-cytochrome c ions", J AM SOC M, 12(7), 2001, pp. 873-876

Abstract

Electrochemical reduction of the iron bound in the heme group of cytochrome c is shown to occur in the nano-electrospray capillary if the protein is sprayed from neutral water using a steel wire as the electrical contact. Quadrupole ion trap collisional activation is used to study the dissociation reactions of cytochrome c as a function of the oxidation state of the iron. Oxidized (Fe(III)) cytochrome c dissociates via sequence-specific amide bond cleavage, while the reduced (Fe(II)) form of the protein dissociates almost exclusively by loss of protonated heme. Apo-cytochrome c, from which the heme has been removed either via gas-phase dissociation of the reduced hole-protein or via solution chemistry, dissociates via amide bond cleavage in similar fashion to the oxidized hole-protein. (C) 2001 American Society for Mass Spectrometry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:29:56