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Titolo:
The neuroprotective and antiapoptotic effects of melatonin in cerebellar neurons involve glucocorticoid receptor and p130 signal pathways
Autore:
Persengiev, SP;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Cellular & Mol Physiol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 hysiol, Worcester, MA 01655 USA
Titolo Testata:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 2-3, volume: 77, anno: 2001,
pagine: 151 - 158
SICI:
0960-0760(200105)77:2-3<151:TNAAEO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE NERVOUS-SYSTEM; RETINOBLASTOMA PROTEIN; POSTNATAL-DEVELOPMENT; TRANSCRIPTION FACTORS; ESTROGEN-RECEPTOR; BINDING-ACTIVITY; CELL BIOLOGY; EXPRESSION; GENE; THYMUS;
Keywords:
antipoptotic; melatonin; neuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Persengiev, SP Univ Massachusetts, Sch Med, Program Mol Med, 2 Biotech,Suite 309,373 Plantat St, Worcester, MA 01655 USA Univ Massachusetts 2 Biotech,Suite 309,373 Plantat St Worcester MA USA 01655
Citazione:
S.P. Persengiev, "The neuroprotective and antiapoptotic effects of melatonin in cerebellar neurons involve glucocorticoid receptor and p130 signal pathways", J STEROID B, 77(2-3), 2001, pp. 151-158

Abstract

Melatonin is an endocrine factor known to affect a number of physiologicalfunctions. The present studies have demonstrated an additional activity for pineal melatonin. specifically associated with the survival and differentiation of neuroblasts. Based on experimental data several conclusions mightbe drawn. First, melatonin negatively regulates the expression of glucocorticoid receptor (GR) in cerebellar granule neurons. Second. downregulation of GR is associated with a marked decrease in programmed cell death of the granule neurons. Third, melatonin upregulates the expression of p130, whichis an essential factor for the initiation and maintenance of neuronal development and differentiation. Thus, melatonin function in postmitotic neurons involves several regulatory pathways with partially overlapping roles. The biological implications are discussed in light of these results. (C) 2001Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:45:28