Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia
Autore:
Ellenbroek, BA; Liegeois, JF; Bruhwyler, J; Cools, AR;
Indirizzi:
Univ Nijmegen, Dept Psychoneuropharmacol, NL-6500 HB Nijmegen, NetherlandsUniv Nijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands Univ Liege, Med Chem Lab, Liege, Belgium Univ Liege Liege BelgiumUniv Liege, Med Chem Lab, Liege, Belgium Therabel Res SA, Brussels, Belgium Therabel Res SA Brussels BelgiumTherabel Res SA, Brussels, Belgium
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 298, anno: 2001,
pagine: 386 - 391
SICI:
0022-3565(200107)298:1<386:EOJAPW>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN RECEPTOR SUBTYPES; PREPULSE INHIBITION; NEUROLEPTIC DRUGS; PAW TEST; NUCLEUS-ACCUMBENS; ACOUSTIC STARTLE; RATS; CLOZAPINE; DERIVATIVES; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Ellenbroek, BA Univ Nijmegen, Dept Psychoneuropharmacol, POB 9101, NL-6500HB Nijmegen, Netherlands Univ Nijmegen POB 9101 Nijmegen Netherlands NL-6500 HB nds
Citazione:
B.A. Ellenbroek et al., "Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia", J PHARM EXP, 298(1), 2001, pp. 386-391

Abstract

JL13 [5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5] benzoxazepinefumarate] is a substance with a close structural resemblance to clozapine. However, it is less sensitive to oxidation and may therefore have less hematological side effects. In the present study, JL13 was compared with clozapine and haloperidol in several animal models for schizophrenia The paw test represents a screening model for antipsychotic drugs that can discriminate between drugs with extrapyramidal side effects and drugs without. Haloperidol increased both forelimb retraction time and hindlimb retraction time (HRT), whereas both clozapine and JL13 increased only HRT. In the prepulse inhibition paradigm, all three drugs reversed the apomorphine and the amphetamine-induced disruption of prepulse inhibition. However, whereas haloperidol was equally effective against both dopaminergic drugs, JL13 and clozapine were more effective against amphetamine. Finally, only JL13 was able to increase prepulse inhibition in normal rats, whereas only clozapine reduced basal startle amplitude. Taken together, these data suggest that JL13 may be an effective antipsychotic drug, with a profile similar to clozapine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:34:23