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Titolo:
Effects of T-588, a cognitive enhancer compound, on synaptic plasticity inthe dentate gyrus of freely moving rats
Autore:
Yamaguchi, H; Tamura, R; Kuriwaki, J; Eifuku, S; Ono, T;
Indirizzi:
Toyama Med & Pharmaceut Univ, Fac Med, Dept Physiol, Toyama 9300194, JapanToyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 298, anno: 2001,
pagine: 354 - 361
SICI:
0022-3565(200107)298:1<354:EOTACE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CEREBRAL CORTICAL SLICES; PERFORANT PATH; POPULATION SPIKE; GRANULE CELLS; RECEPTOR ANTAGONIST; HYDROCHLORIDE T-588; ANESTHETIZED RATS; FIELD POTENTIALS; NMDA ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Ono, T Toyama Med & Pharmaceut Univ, Fac Med, Dept Physiol, 2630 Sugitani,Toyama9300194, Japan Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194 an
Citazione:
H. Yamaguchi et al., "Effects of T-588, a cognitive enhancer compound, on synaptic plasticity inthe dentate gyrus of freely moving rats", J PHARM EXP, 298(1), 2001, pp. 354-361

Abstract

(1R)-1-benzo [b] thiophen-5-yl-2-[2-(diethylamino) ethoxy] ethan-1-ol hydrochloride (T-588) is a compound for the treatment of neurodegenerative disorders, including Alzheimer's disease and cerebrovascular diseases. T-588 reportedly alleviates learning and memory deficits in animal models of dementia. In the present study, we investigated the effects of T-588 on the induction and decay of long-term potentiation (LTP) and on the responses to paired-pulse (pp) stimulation in freely moving rats. Perforant path-evoked field potentials were recorded in the dentate gyrus by chronically implanted electrodes. LTP was induced by high-frequency stimulation 30 min after oral administration of T-588 (0.3 or 3 mg/kg), T-588 significantly augmented the increase in population spike amplitude and field excitatory postsynaptic potential slope after LTP induction, T-588 also prolonged the decay of augmented population spike amplitude, but had no significant effect on the response to pp stimulation, These results suggest that T-588 facilitates long-term synaptic plasticity, but not shortterm synaptic plasticity in the dentategyrus of freely moving rats. The effect of T-588 on long-term synaptic plasticity may contribute to the alleviation of learning and memory dysfunction seen in animal models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:47:09