Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differential effects of alpha-adrenoceptor agonists on human retinal microvessel diameter
Autore:
Spada, CS; Nieves, AL; Burke, JA; Wheeler, LA; Woodward, DF;
Indirizzi:
Allergan Pharmaceut Inc, Dept Biol Sci RD2C, Pharmaceut Res & Dev, Irvine,CA 92612 USA Allergan Pharmaceut Inc Irvine CA USA 92612 es & Dev, Irvine,CA 92612 USA
Titolo Testata:
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
fascicolo: 3, volume: 17, anno: 2001,
pagine: 255 - 277
SICI:
1080-7683(200106)17:3<255:DEOAAO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMIDAZOLINE BINDING-SITES; VASCULAR SMOOTH-MUSCLE; HAMSTER-CHEEK POUCH; INTRAOCULAR-PRESSURE ELEVATION; ARGON-LASER TRABECULOPLASTY; BRIMONIDINE TARTRATE; CATARACT-EXTRACTION; OXYGEN-TENSION; MICROVASCULAR RESPONSES; 1-PERCENT APRACLONIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Spada, CS Allergan Pharmaceut Inc, Dept Biol Sci RD2C, Pharmaceut Res & Dev, 2525B Dupont Dr, Irvine, CA 92612 USA Allergan Pharmaceut Inc 2525B Dupont Dr Irvine CA USA 92612 USA
Citazione:
C.S. Spada et al., "Differential effects of alpha-adrenoceptor agonists on human retinal microvessel diameter", J OCUL PH T, 17(3), 2001, pp. 255-277

Abstract

The effects of locally administered brimonidine, clonidine, and p-aminoclonidine on microvessel caliber were compared in human retinal tissues grafted into the hamster cheek pouch. Clonidine and p-aminoclonidine, but not brimonidine, potently constricted human retinal microvessels over a broad concentration range. All three agonists elicited significant vasoconstriction in naive hamster cheek pouch microvasculature. The alpha (2)-adrenoceptor antagonist, rauwolscine, inhibited p-aminoclonidine-induced constriction in naive hamster cheek pouch microvessels, but not p-aminoclonidine-induced effects in retinal grafts. Selective alpha (1)-adrenoceptor agonists evoked vasoconstriction in retinal grafts only at relatively high concentrations. These differential effects on the retinal microvasculature could not be readily explained solely on the basis of alpha (1)- or alpha (2)-adrenoceptor involvement. Clonidine, p-aminoclonidine and brimonidine are also imidazolinederivatives that interact with putative non-adrenergic imidazoline-sensitive binding sites, the so-called II-imidazoline binding site subtype implicated by some investigators in mediation of peripheral vasoconstriction. As with p-aminoclonidifie, the potent vasoconstriction in human retinal microvasculature elicited by moxonidine, an alpha -adrenergic agonist that has also been reported to exhibit selectivity for putative I-1-imidazoline bindingsites, was not inhibited by the selective alpha -adrenoceptor antagonist, rauwolscine, nor by idazoxan, an antagonist characterized as having substantial activity at putative I-2-imidazoline binding sites. These data suggestthe possible involvement of an unconventional non-adrenergic imidazoline-sensitive pathway in regulation of microvascular responses in the inner retina, and that drug activity mediated via such an imidazoline-sensitive component could potentially evoke deleterious effects in the retinal microvasculature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:25:42