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Titolo:
Plasma concentration of topically applied betaxolol in elderly glaucoma patients
Autore:
Vainio-Jylha, E; Vuori, ML; Pyykko, K; Huupponen, R;
Indirizzi:
Univ Turku, Dept Ophthalmol, SF-20500 Turku, Finland Univ Turku Turku Finland SF-20500 pt Ophthalmol, SF-20500 Turku, Finland
Titolo Testata:
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
fascicolo: 3, volume: 17, anno: 2001,
pagine: 207 - 213
SICI:
1080-7683(200106)17:3<207:PCOTAB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIMOLOL-INDUCED BRONCHOSPASM; ASTHMATIC BRONCHITIS; RECEPTOR-BINDING; OCULAR TIMOLOL; BETA-BLOCKERS; AGENT; PHARMACOKINETICS; ABSORPTION; KINETICS; ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Vainio-Jylha, E Turku Univ Hosp, Dept Ophthalmol, Kiinamyllynkatu 4-8, SF-20520 Turku, Finland Turku Univ Hosp Kiinamyllynkatu 4-8 Turku Finland SF-20520
Citazione:
E. Vainio-Jylha et al., "Plasma concentration of topically applied betaxolol in elderly glaucoma patients", J OCUL PH T, 17(3), 2001, pp. 207-213

Abstract

Our aim was to study the concentration of betaxolol in plasma after its topical ocular use during the normal 12 hr dosing interval. Twenty microliters of betaxolol 0.5% solution were applied into both eyes of nine glaucoma patients, and the plasma concentrations of the drug were measured 12 hr thereafter using a radioreceptor assay. The same amount of betaxolol was then applied ocularly, and its concentration in plasma was measured at 5, 10, 15,30 min and 1, 2, 4 and 8 hr thereafter. The mean (SD) concentration of betaxolol in plasma twelve hr after the first dose was 0.4 (0.2) ng/ml. After the second dose, the patients showed a biphasic concentration vs, time curve, the first peak occurring at 8 (4) min, and the second peak at 210 (132) min. the mean (SD) peak concentrations being 1.1 (0.3) and 2.0 (1.1) ng/ml,respectively. The area under the concentration vs, time curve showed a 4-fold variation among our patients. Topically applied betaxolol was rapidly absorbed into systemic circulation, and concentrations were detectable even at 12 hr. The interindividual variation in the systemic absorption of betaxolol was large.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:55:56