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Titolo:
Effects of alterations in arterial CO2 tension on cerebral blood flow during acute intracranial hypertension in rats
Autore:
Hauerberg, J; Ma, XD; Bay-Hansen, R; Pedersen, DB; Rochat, P; Juhler, M;
Indirizzi:
Rigshosp, Dept Neurosurg, DK-2100 Copenhagen, Denmark Rigshosp Copenhagen Denmark DK-2100 urosurg, DK-2100 Copenhagen, Denmark Rigshosp, Ctr Neurosci, Neurobiol Res Unit, DK-2100 Copenhagen, Denmark Rigshosp Copenhagen Denmark DK-2100 es Unit, DK-2100 Copenhagen, Denmark
Titolo Testata:
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 213 - 221
SICI:
0898-4921(200107)13:3<213:EOAIAC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBON-DIOXIDE; REACTIVITY; AUTOREGULATION; HEMODYNAMICS; HYPOTENSION; RESPONSES;
Keywords:
carbon dioxide; cerebral blood flow; cerebral perfusion pressure; cerebrovascular reactivity; CO2 reactivity; intracranial hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hauerberg, J Rigshosp, Dept Neurosurg, NK 2091, DK-2100 Copenhagen, Denmark Rigshosp NK 2091 Copenhagen Denmark DK-2100 enhagen, Denmark
Citazione:
J. Hauerberg et al., "Effects of alterations in arterial CO2 tension on cerebral blood flow during acute intracranial hypertension in rats", J NEUROS AN, 13(3), 2001, pp. 213-221

Abstract

Cerebrovascular reactivity to CO2 in clinical and experimental studies hasbeen found to be impaired during increased intracranial pressure (ICP). However, from previous study results it has not been possible to estimate whether the impairment was caused by elevated ICP, or caused by decreased cerebral perfusion pressure (CPP). The current study was carried out in a groupof unmanipulated control rats and in six investigation groups of six rats each: two groups with elevated ICP (30 and 50 mm Hg) and spontaneous arterial blood pressure (MABP), two groups with spontaneous ICP and arterial hypotension (77 and 64 mm Hg), and two groups with elevated ICP (30 and 50 mm HE) and arterial hypertension (124 mm Hg). Intracranial hypertension was induced by continuous infusion of lactated Ringer's solution into the cisternamagna, arterial hypotension by controlled bleeding, and arterial hypertension by continuous administration of norepinephrine intravenously. Cerebral blood flow (CBF) was measured repetitively by the intraarterial Xe-133 method at different levels of arterial PCO2. In each individual animal, CO2 reactivity was calculated from an exponential regression line obtained from the corresponding CBF/PaCO2 values. By plotting each individual value of CO2 reactivity against the corresponding CPP value from the seven investigationgroups, CPP was significantly and directly related to CO2 reactivity of CBF (P < .001). No correlation was found by plotting CO2 reactivity values against the corresponding MABP values or the corresponding ICP values. Thus, the results show that CO2 reactivity is at least partially determined by CPP and that the impaired CO2 reactivity observed at intracranial hypertension and arterial hypotension may be caused by reduced CPP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:33:46