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Titolo:
Effect of a subanesthetic dose of intravenous ketamine and/or local anesthetic infiltration on hemodynamic responses to skull-pin placement - A prospective, placebo-controlled, randomized, double-blind study
Autore:
Agarwal, A; Sinha, PK; Pandey, CM; Gaur, A; Pandey, CK; Kaushik, S;
Indirizzi:
Sanjay Gandhi Postgrad Inst Med Sci, Dept Anesthesiol & Crit Care Med, Lucknow 226014, Uttar Pradesh, India Sanjay Gandhi Postgrad Inst Med Sci Lucknow Uttar Pradesh India 226014 ia Sanjay Gandhi Postgrad Inst Med Sci, Dept Biostat, Lucknow 226014, Uttar Pradesh, India Sanjay Gandhi Postgrad Inst Med Sci Lucknow Uttar Pradesh India 226014 ia
Titolo Testata:
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 189 - 194
SICI:
0898-4921(200107)13:3<189:EOASDO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIN; INDUCTION; RECEPTOR;
Keywords:
craniotomy; head pinning; ketamine; subanesthetic dose; hemodynamics; postanesthesia recovery; brain conditions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Agarwal, A Sanjay Gandhi Postgrad Inst Med Sci, Dept Anesthesiol & Crit Care Med, Type IV-48, Lucknow 226014, Uttar Pradesh, India Sanjay Gandhi Postgrad Inst Med Sci Type IV-48 Lucknow Uttar Pradesh India 226014
Citazione:
A. Agarwal et al., "Effect of a subanesthetic dose of intravenous ketamine and/or local anesthetic infiltration on hemodynamic responses to skull-pin placement - A prospective, placebo-controlled, randomized, double-blind study", J NEUROS AN, 13(3), 2001, pp. 189-194

Abstract

Insertion of cranial pins for stabilization of the head can result in a marked hypertensive response, which may adversely affect cerebral hemodynamics. The efficacy of a subanesthetic dose of intravenous ketamine (0.5 mg/kg)and/or lidocaine infiltration (1%) at pin fixation sites before pinning was studied in a prospective, double-blind, placebo-controlled, randomized trial of 40 patients. The subjects were divided into four groups of 10. Patients belonging to the placebo and lidocaine groups received intravenous normal saline (NS), followed by local infiltration with NS at pin insertion sites in the placebo group and 1% lidocaine in the lidocaine group. Patients belonging to the ketamine and ketamine-lidocaine groups received intravenousketamine followed by local infiltration with NS in the ketamine group, andlidocaine infiltration in the ketamine-lidocaine group. Heart rate (HR) and invasive mean blood pressure (MBP) were recorded before intravenous medication and then at various time intervals until 15 minutes after pin fixation. Intergroup comparison of MBP and HR by 2-way analysis of variance revealed a significant difference between the groups and various time points (P <.05). Post hoc analysis revealed maximum increase in MBP each hour in the placebo group. Mean blood pressure response in the ketamine group was similar to the placebo group. Significant attenuation of MBP and HR was observedin the lidocaine and ketamine-lidocaine groups (P < .05). A minimal increase in HR was observed in the lidocaine-ketamine group. The current study demonstrates maximum attenuation of hemodynamic responses when a subanesthetic dose of intravenous ketamine (0.5 mg/kg) is administered with 1% lidocaine infiltration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:37:55