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Titolo:
Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons
Autore:
Floresco, SB; Todd, CL; Grace, AA;
Indirizzi:
Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 eurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 sychiat, Pittsburgh, PA 15260 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 13, volume: 21, anno: 2001,
pagine: 4915 - 4922
SICI:
0270-6474(20010701)21:13<4915:GAFTHT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; METHYL-D-ASPARTATE; IN-VIVO; LOCOMOTOR-ACTIVITY; EXTRACELLULAR DOPAMINE; ELECTRICAL-STIMULATION; IDENTIFIED NEURONS; NMDA RECEPTORS; RAT; SUBICULUM;
Keywords:
ventral subiculum; ventral tegmental area; nucleus accumbens; NMDA; glutamate; dopamine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Floresco, SB Univ Pittsburgh, Dept Neurosci, 446 Crawford Hall, Pittsburgh, PA 15260 USA Univ Pittsburgh 446 Crawford Hall Pittsburgh PA USA 15260 USA
Citazione:
S.B. Floresco et al., "Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons", J NEUROSC, 21(13), 2001, pp. 4915-4922

Abstract

Several studies have shown that the mesolimbic dopamine (DA) system is strongly influenced by the ventral subiculum (vSub) of the hippocampus. To examine whether this occurs by activation of DA neuron firing, the effects of chemical stimulation of the vSub on ventral tegmental area (VTA) DA neuron activity were examined using extracellular single-unit recordings. Infusions of NMDA into the vSub increased the number of spontaneously firing DA cells recorded per electrode track, while having no effect on firing rate or burst firing. This response was abolished by intranucleus accumbens (NAc) infusions of the glutamate receptor antagonist kynurenic acid. This effect did not involve the prefrontal cortex, because infusions of tetrodotoxin intothe prefrontal cortex did not affect the increase in spontaneously active DA cells. Infusions of either kynurenic acid into the NAc or tetrodotoxin into the vSub decreased the firing rate and burst firing of DA neurons without altering the number of spontaneously active DA neurons. These data show that glutamatergic afferents from the vSub to the NAc exert a potent excitatory effect on VTA DA neurons, influencing both DA neuron population activity and the regulation of the firing properties of these neurons. As a result, dysfunctions in hippocampal circuitries may contribute to the hyperexcitable state of the DA system that is present in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:46:18