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Titolo:
The alpha(2A)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety
Autore:
Schramm, NL; McDonald, MP; Limbird, LE;
Indirizzi:
Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ, Sch Med, Ctr Mol Neurosci, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Neurosci, Nashville, TN 37232 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 13, volume: 21, anno: 2001,
pagine: 4875 - 4882
SICI:
0270-6474(20010701)21:13<4875:TARPAP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORCED SWIMMING TEST; SINGLE-UNIT RESPONSE; OPEN-FIELD BEHAVIOR; FREELY MOVING CATS; LOCUS-COERULEUS; NORADRENERGIC NEURONS; PRESENTED STRESSFUL; ANXIOLYTIC ACTIVITY; KNOCKOUT MICE; DORSAL RAPHE;
Keywords:
antidepressant; adrenergic receptor; anxiety; forced swim; imipramine; light-dark test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Schramm, NL Vanderbilt Univ, Med Ctr, Dept Physiol & Mol Biophys, 724B MRB1,23rd Ave S & Pierce, Nashville, TN 37232 USA Vanderbilt Univ 724B MRB 1,23rd Ave S & Pierce Nashville TN USA 37232
Citazione:
N.L. Schramm et al., "The alpha(2A)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety", J NEUROSC, 21(13), 2001, pp. 4875-4882

Abstract

The noradrenergic system is involved in the regulation of many physiological and psychological processes, including the modulation of mood. The alpha(2)-adrenergic receptors (alpha (2)-ARs) modulate norepinephrine release, as well as the release of serotonin and other neurotransmitters, and are therefore potential targets for antidepressant and anxiolytic drug development. The current studies were undertaken to examine the role of the alpha (2A) subtype of alpha (2)-AR in mouse behavioral models of depression and anxiety. We have observed that the genetic knock-out of the alpha (2A)-AR makesmice less active in a modified version of Porsolt's forced swim test and insensitive to the antidepressant effects of the tricyclic drug imipramine in this paradigm. Furthermore, alpha (2A)-AR knock-out mice appear more anxious than wild-type C57Bl/6 mice in the rearing and light-dark models of anxiety after injection stress. These findings suggest that the alpha (2A)-AR may play a protective role in some forms of depression and anxiety and thatthe antidepressant effects of imipramine may be mediated by the alpha (2A)-AR.

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Documento generato il 09/04/20 alle ore 20:09:06