Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Reversible inactivation of the dorsal nucleus of the lateral lemniscus reveals its role in the processing of multiple sound sources in the inferior colliculus of bats
Autore:
Burger, RM; Pollak, GD;
Indirizzi:
Univ Texas, Neurobiol Sect, Austin, TX 78712 USA Univ Texas Austin TX USA78712 exas, Neurobiol Sect, Austin, TX 78712 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 13, volume: 21, anno: 2001,
pagine: 4830 - 4843
SICI:
0270-6474(20010701)21:13<4830:RIOTDN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
IPSILATERALLY EVOKED INHIBITION; TADARIDA-BRASILIENSIS-MEXICANA; INTERAURAL TIME DIFFERENCES; SUPERIOR OLIVARY COMPLEX; FREE-TAILED BATS; 60-KHZ EI UNITS; MOUSTACHE BAT; RESPONSE PROPERTIES; BINAURAL RESPONSES; GABAERGIC INHIBITION;
Keywords:
GABA; persistent inhibition; precedence effect; inferior colliculus; sound localization; dorsal nucleus of lateral lemniscus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Pollak, GD Univ Texas, Neurobiol Sect, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 biol Sect, Austin, TX 78712 USA
Citazione:
R.M. Burger e G.D. Pollak, "Reversible inactivation of the dorsal nucleus of the lateral lemniscus reveals its role in the processing of multiple sound sources in the inferior colliculus of bats", J NEUROSC, 21(13), 2001, pp. 4830-4843

Abstract

Neurons in the inferior colliculus (IC) that are excited by one ear and inhibited by the other [excitatory-inhibitory (EI) neurons] can code interaural intensity disparities (IIDs), the cues animals use to localize high frequencies. Although EI properties are first formed in a lower nucleus and imposed on some IC cells via an excitatory projection, many other EI neurons are formed de novo in the IC. By reversibly inactivating the dorsal nucleus of the lateral lemniscus (DNLL) in Mexican free-tailed bats with kynurenic acid, we show that the EI properties of many IC cells are formed de novo via an inhibitory projection from the DNLL on the opposite side. We also showthat signals excitatory to the IC evoke an inhibition in the opposite DNLLthat persists for tens of milliseconds after the signal has ended. During that period, strongly suppressed EI cells in the IC are deprived of inhibition from the DNLL and respond to binaural signals as weakly inhibited or monaural cells. By relieving inhibition at the IC, we show that an initial binaural signal essentially reconfigures the circuit and thereby allows IC cells to respond to trailing binaural signals that were inhibitory when presented alone. Thus, DNLL innervation creates a property in the IC that is notpossessed by lower neurons or by collicular EI neurons that are not innervated by the DNLL. That property is a change in responsiveness to binaural signals, a change dependent on the reception of an earlier sound. These features suggest that the circuitry linking the DNLL with the opposite central nucleus of the IC is important for the processing of IIDs that change over time, such as the IIDs generated by moving stimuli or by multiple sound sources that emanate from different regions of space.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:40:54