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Titolo:
Psychological stress increases hippocampal mineralocorticoid receptor levels: Involvement of corticotropin-releasing hormone
Autore:
Gesing, A; Bilang-Bleuel, A; Droste, SK; Linthorst, ACE; Holsboer, F; Reul, JMHM;
Indirizzi:
Max Planck Inst Psychiat, Sect Neuropsychopharmacol, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 13, volume: 21, anno: 2001,
pagine: 4822 - 4829
SICI:
0270-6474(20010701)21:13<4822:PSIHMR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
II CORTICOSTEROID RECEPTORS; PITUITARY-ADRENOCORTICAL SYSTEM; ADRENAL-STEROID RECEPTORS; RAT-BRAIN; GENE-EXPRESSION; GLUCOCORTICOID RECEPTORS; PARAVENTRICULAR NUCLEUS; FUNCTIONAL IMPLICATIONS; ALZHEIMERS-DISEASE; DEPRESSED-PATIENTS;
Keywords:
mineralocorticoid receptor; HPA axis; corticotropin-releasing hormone; ACTH; glucocorticoid hormone; hippocampus; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Reul, JMHM Max Planck Inst Psychiat, Sect Neuropsychopharmacol, Kraepelinstr 2, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 2 Munich Germany D-80804
Citazione:
A. Gesing et al., "Psychological stress increases hippocampal mineralocorticoid receptor levels: Involvement of corticotropin-releasing hormone", J NEUROSC, 21(13), 2001, pp. 4822-4829

Abstract

We investigated whether acute stressors regulate functional properties of the hippocampal mineralocorticoid receptor (MR), which acts inhibitory on hypothalamic-pituitary-adrenocortical activity. Exposure of rats to forced swimming or novelty evoked a significant rise in density of MR immunoreactivity in all hippocampal subfields after 24 hr, whereas exposure to a cold environment was ineffective. Time course analysis revealed that the effect offorced swimming on MR peaked at 24 hr and returned to control levels between 24 and 48 hr. In pyramidal neurons of CA2 and CA3, marked rises were already observed after 8 hr. Radioligand binding assays showed that corticotropin-releasing hormone (CRH) injected intracerebroventricularly into adrenalectomized rats also produced a rise in hippocampal MR levels; an effect forwhich the presence of corticosterone, but not dexamethasone, at the time of injection was a prerequisite. Moreover, pretreatment with the CRH receptor antagonist (D-Phe(12),Nle(21,38),alpha -Me-Leu(37))-CRH12-41 blocked the effect of forced swimming on hippocampal MR levels. To investigate whether the rise in MR levels had any functional consequences for HPA regulation, 24 hr after forced swimming, a challenge test with the MR antagonist RU 28318 was conducted. The forced swimming exposed rats showed an enhanced MR-mediated inhibition of HPA activity. This study identifies CRH as an important regulator of MR, a pathway with marked consequence for HPA axis regulation. We conclude that the interaction between CRH and MR presents a novel mechanism involved in the adaptation of the brain to psychologically stressful events.

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Documento generato il 20/01/20 alle ore 07:36:13