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Titolo:
A code for behavioral inhibition on the basis of color, but not motion, inventrolateral prefrontal cortex of macaque monkey
Autore:
Sakagami, M; Tsutsui, K; Lauwereyns, J; Koizumi, M; Kobayashi, S; Hikosaka, O;
Indirizzi:
Tamagawa Univ, Brain Sci Res Ctr, Tokyo 1948610, Japan Tamagawa Univ Tokyo Japan 1948610 rain Sci Res Ctr, Tokyo 1948610, Japan Juntendo Univ, Sch Med, Dept Physiol, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 ysiol, Bunkyo Ku, Tokyo 1138421, Japan Univ Tokyo, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 t Neurol, Bunkyo Ku, Tokyo 1138655, Japan Nihon Univ, Sch Med, Dept Physiol, Itabashi Ku, Tokyo 1738610, Japan NihonUniv Tokyo Japan 1738610 hysiol, Itabashi Ku, Tokyo 1738610, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 13, volume: 21, anno: 2001,
pagine: 4801 - 4808
SICI:
0270-6474(20010701)21:13<4801:ACFBIO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL EYE FIELD; RHESUS-MONKEYS; NEURAL ACTIVITY; MACACA-FUSCATA; VISUAL-CORTEX; UNIT-ACTIVITY; AREA V4; NEURONS; ATTENTION; DISCRIMINATION;
Keywords:
inhibitory control; ventrolateral prefrontal cortex; macaque monkey; go/no-go task; selective attention; color; random dot motion; single unit; ventral pathway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Sakagami, M Tamagawa Univ, Brain Sci Res Ctr, Tamagawa Gakuen 6-1-1, Tokyo1948610, Japan Tamagawa Univ Tamagawa Gakuen 6-1-1 Tokyo Japan 1948610 Japan
Citazione:
M. Sakagami et al., "A code for behavioral inhibition on the basis of color, but not motion, inventrolateral prefrontal cortex of macaque monkey", J NEUROSC, 21(13), 2001, pp. 4801-4808

Abstract

To examine the neural mechanism for behavioral inhibition, we recorded single-cell activity in macaque ventrolateral prefrontal cortex, which is known to receive visual information directly from the inferotemporal cortex. Inresponse to a moving random pattern of colored dots, monkeys had to make ago or no-go response. In the color condition, green indicated go, whereas red indicated no-go, regardless of the motion direction; in the motion condition, upward indicated go, whereas downward indicated no-go, regardless ofthe color. Approximately one-half of the visual cells were go/no-go differential. A majority of these cells (64/73) showed differential activity onlyin the color condition; they responded nondifferentially in the motion condition, although the same set of stimuli was used. We classified these cells as "go type" (n = 41) and "no-go type" (n = 23) depending on the color for which they showed a stronger response. Interestingly, in both types of cells, the differential effects were observed only for the no-go-indicating color. Compared with the nondifferential responses in the motion condition, go-type cells in the color condition showed weaker responses to the no-go-indicating color, whereas their responses to the go-indicating color were similar; in contrast, no-go type cells showed stronger responses to the no-go-indicating color, whereas their responses to the go-indicating color were similar. Both types of cells did not show any activity change during the actual execution of the go or no-go response. These results suggest that neurons in ventrolateral prefrontal cortex contribute to stimulus-response association in complex task situations by inhibiting behavioral responses on the basis of visual information from the ventral stream.

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Documento generato il 19/01/20 alle ore 20:22:14