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Titolo:
Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear
Autore:
Zine, A; Aubert, A; Qiu, JP; Therianos, S; Guillemot, F; Kageyama, R; de Ribaupierre, F;
Indirizzi:
Univ Lausanne, Inst Physiol, CH-1005 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1005 CH-1005 Lausanne, Switzerland Ctr Univ Strasbourg, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch,France Ctr Univ Strasbourg Illkirch France F-67404 ire, F-67404 Illkirch,France Kyoto Univ, Inst Virus Res, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 niv, Inst Virus Res, Kyoto 6068507, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 13, volume: 21, anno: 2001,
pagine: 4712 - 4720
SICI:
0270-6474(20010701)21:13<4712:HAHAAR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOOP-HELIX FACTORS; DEVELOPING NERVOUS-SYSTEM; NOTCH SIGNALING PATHWAY; NEGATIVE REGULATOR; NEUROGENIC GENES; EXPRESSION; DIFFERENTIATION; DROSOPHILA; ENHANCER; COCHLEA;
Keywords:
Hes1; Hes5; Math1; basic helix-loop-helix (bHLH); transcriptions factors; mouse mutant; cochlea; utricle; saccule; hair cell differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Zine, A Univ Lausanne, Inst Physiol, 7 Rue Bugnon, CH-1005 Lausanne, Switzerland Univ Lausanne 7 Rue Bugnon Lausanne Switzerland CH-1005 itzerland
Citazione:
A. Zine et al., "Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear", J NEUROSC, 21(13), 2001, pp. 4712-4720

Abstract

The mammalian inner ear contains two sensory organs, the cochlea and vestibule. Their sensory neuroepithelia are characterized by a mosaic of hair cells and supporting cells. Cochlear hair cells differentiate in four rows: asingle row of inner hair cells (IHCs) and three rows of outer hair cells (OHCs). Recent studies have shown that Math1, a mammalian homolog of Drosophila atonal is a positive regulator of hair cell differentiation. The basic helix-loop-helix (bHLH) genes Hes1 and Hes5 (mammalian hairy and Enhancer-of-split homologs) can influence cell fate determination by acting as negative regulators to inhibit the action of bHLH-positive regulators. We show byusing reverse transcription-PCR analysis that Hes1, Hes5, and Math1 are expressed in the developing mouse cochleae. In situ hybridization revealed a widespread expression of Hes1 in the greater epithelial ridge (GER) and in lesser epithelial ridge (LER) regions. Hes5 is predominantly expressed in the LER, in supporting cells, and in a narrow band of cells within the GER. Examination of cochleae from Hes1(-/-) mice showed a significant increase in the number of IHCs, whereas cochleae from Hes5(-/-) mice showed a significant increase in the number of OHCs. In the vestibular system, targeted deletion of Hes1 and to a lesser extent Hes5 lead to formation of supernumerary hair cells in the saccule and utricle. The supernumerary hair cells in the mutant mice showed an upregulation of Math1. These data indicate that Hes1 and Hes5 participate together for the control of inner ear hair cell production, likely through the negative regulation of Math1.

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Documento generato il 24/11/20 alle ore 14:26:39