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Titolo:
Kainate receptors expressed by a subpopulation of developing nociceptors rapidly switch from high to low Ca2+ permeability
Autore:
Lee, CJ; Kong, HY; Manzini, MC; Albuquerque, C; Chao, MV; MacDermott, AB;
Indirizzi:
Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA Columbia Univ New York NY USA 10032 lular Biophys, New York, NY 10032 USA Columbia Univ, Dept Pathol, New York, NY 10032 USA Columbia Univ New YorkNY USA 10032 , Dept Pathol, New York, NY 10032 USA Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ New York NY USA 10032 obiol & Behav, New York, NY 10032 USA NYU Med Ctr, Skirball Inst, Mol Neurobiol Program, New York, NY 10016 USA NYU Med Ctr New York NY USA 10016 urobiol Program, New York, NY 10016 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 13, volume: 21, anno: 2001,
pagine: 4572 - 4581
SICI:
0270-6474(20010701)21:13<4572:KREBAS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; CEREBELLAR GRANULE CELLS; DORSAL HORN; AMPA RECEPTORS; GLUTAMATE-RECEPTOR; CAPSAICIN RECEPTOR; NMDA RECEPTORS; ION CHANNELS; DRG NEURONS; ACTIVATION;
Keywords:
dorsal root ganglion; nociceptor; kainate receptor; calcium permeability; capsaicin; LD2; LA4; IB4; lamina II; C-fiber;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, CJ Columbia Univ, Dept Physiol & Cellular Biophys, 630 W 168th St,BB1106, NewYork, NY 10032 USA Columbia Univ 630 W 168th St,BB1106 New York NY USA 10032 0032 USA
Citazione:
C.J. Lee et al., "Kainate receptors expressed by a subpopulation of developing nociceptors rapidly switch from high to low Ca2+ permeability", J NEUROSC, 21(13), 2001, pp. 4572-4581

Abstract

Dorsal root ganglion (DRG) neurons first express kainate receptor subunits, predominantly GluR5, during embryonic development. In the DRG and throughout the nervous system, substantial editing of GluR5 mRNA occurs with developmental maturation (Bernard et al., 1999). The accompanying change in Ca2permeability of functional kainate receptors that is the predicted outcomeof this developmental regulation of mRNA editing has not been investigated. Here we report that kainate receptors on DRG neurons from late embryonic and newborn rats are predominantly Ca2+ permeable but then become fully Ca2 impermeable later in the first postnatal week. Using multiple markers fornociceptor subpopulations, we show that this switch in Ca2+ permeability is not caused by the appearance of a new subpopulation of nociceptors with different receptor properties. Instead, the change in Ca2+ permeability matches the time course of post-transcriptional RNA editing of GluR5 at the Q/Rsite within the pore of the channel, indicating that the change is probably caused by developmentally regulated RNA editing. We also report that, on the basis of the strong correlation of receptor expression with expression of the surface markers LA4, isolectin B4, and LD2, kainate receptors are present on C-fiber-type neurons projecting to lamina II of spinal cord dorsalhorn. These results raise the possibility that kainate receptors in their Ca2+-permeable form serve a developmental role in synapse formation betweenthis population of C-fibers and their targets in the spinal cord dorsal horn. Thereafter, the receptors may serve a new function that does not require Ca2+ permeability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:16:23