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Titolo:
Vestibular function in severe bilateral vestibulopathy
Autore:
Wiest, G; Demer, JL; Tian, J; Crane, BT; Baloh, RW;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Neurol, Reed Neurol Res Ctr, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Jules Stein Eye Inst, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 1, volume: 71, anno: 2001,
pagine: 53 - 57
SICI:
0022-3050(200107)71:1<53:VFISBV>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORIZONTAL VESTIBULOOCULAR REFLEX; HIGH-ACCELERATION ROTATIONS; SQUIRREL-MONKEY; OCULAR REFLEX; RESPONSES; DEFICITS; PURSUIT; MOTION; HEAD; MECHANISMS;
Keywords:
bilateral vestibulopathy; vestibulo-ocular reflex; high acceleration rotation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Demer, JL Univ Calif Los Angeles, Sch Med, Dept Neurol, Reed Neurol Res Ctr, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 s, CA 90024 USA
Citazione:
G. Wiest et al., "Vestibular function in severe bilateral vestibulopathy", J NE NE PSY, 71(1), 2001, pp. 53-57

Abstract

Objectives-To assess residual vestibular function in patients with severe bilateral vestibulopathy comparing low frequency sinusoidal rotation with the novel technique of random, high acceleration rotation of the whole body. Methods-Eye movements were recorded by electro-oculography in darkness during passive, whole body sinusoidal yaw rotations at frequencies between 0.05 and 1.6 Hz in four patients who had absent caloric vestibular responses. These were compared with recordings using magnetic search coils during the first 100 ms after onset of whole body yaw rotation at peak accelerations of 2800 degrees /s(2). Off centre rotations added novel information about otolithic function. Results-Sinusoidal yaw rotations at 0.05 Hz, peak veocity 240 degrees /s yielded minimal responses, with gain (eye velocity/head velocity)<0.02, but gain increased and phase decreased at frequencies between 0.2 and 1.6 Hz ina manner resembling the vestibule-ocular reflex. By contrast, the patientshad profoundly attenuated responses to both centred and eccentric high acceleration transients, representing virtually absent responses to this powerful vestibular stimulus. Conclusion-The analysis of the early ocular response to random, high acceleration rotation of the whole body disclosed a profound deficit of semicircular canal and otolith function in patients for whom higher frequency sinusoidal testing was only modestly abnormal. This suggests that the high frequency responses during sinusoidal rotation were of extravestibular origin. Contributions from the somatosensory or central predictor mechanisms, might account for the generation of these responses. Random, transient rotation is better suited than steady state rotation for quantifying vestibular function in vestibulopathic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/10/20 alle ore 23:32:43