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Titolo:
Dopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients
Autore:
Garcia-Barcelo, MM; Lam, LCW; Ungvari, GS; Lam, VKL; Tang, WK;
Indirizzi:
Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China oples R China
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 6, volume: 108, anno: 2001,
pagine: 671 - 677
SICI:
0300-9564(2001)108:6<671:DDRGAT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASSOCIATION; POLYMORPHISM; PREVALENCE; VARIANT;
Keywords:
schizophrenia; tardive dyskinesia; D3 receptor gene; genetic polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ungvari, GS Prince Wales Hosp, Dept Psychiat, 11-F, Shatin, Hong Kong, Peoples R China Prince Wales Hosp 11-F Shatin Hong Kong Peoples R China China
Citazione:
M.M. Garcia-Barcelo et al., "Dopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients", J NEURAL TR, 108(6), 2001, pp. 671-677

Abstract

Epidemiological studies have shown a lower prevalence of tardive dyskinesia (TD) among Chinese psychiatric patients compared to Caucasian and Black patient populations. It has been hypothesized that pharmacogenetic factors may underlie this cross-cultural difference. Due to the important implications of the dopamine D3 receptor gene (DRD3) in motor control, we investigated the frequency of polymorphic serine (ser) to glycine (gly) substitution of the gene DRD3 in Chinese schizophrenic patients. The sample size consisted of 65 patients with TD and 66 without TD. Patients were assessed for the severity of TD, the presence of akathisia and parkinsonian symptoms and were subsequently genotyped. We found no evidence that the dopamine D3 receptor gene is likely to confer susceptibility to the development of tardive dyskinesia in Chinese patients with schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:36:40