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Titolo:
Systemic lupus erythematosus complicated with cerebral venous sinus thrombosis: A report of two cases
Autore:
Lee, MK; Kim, JH; Kang, HR; Rho, HJ; Nam, EJ; Kim, SW; Kang, YM; Lee, JM; Kim, NS;
Indirizzi:
Kyungpook Natl Univ, Sch Med, Dept Internal Med, Taegu 702701, South KoreaKyungpook Natl Univ Taegu South Korea 702701 , Taegu 702701, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 3, volume: 16, anno: 2001,
pagine: 351 - 354
SICI:
1011-8934(200106)16:3<351:SLECWC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
VEIN-THROMBOSIS; ANTICARDIOLIPIN; ANTICOAGULANT; ANTIBODIES;
Keywords:
systemic lupus erythematosus; sinus thrombosis, intracranial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, JM Kyungpook Natl Univ Hosp, Dept Internal Med, 50 Samduk 2 Ga, Taegu700721,South Korea Kyungpook Natl Univ Hosp 50 Samduk 2 Ga Taegu South Korea 700721
Citazione:
M.K. Lee et al., "Systemic lupus erythematosus complicated with cerebral venous sinus thrombosis: A report of two cases", J KOR MED S, 16(3), 2001, pp. 351-354

Abstract

A rare manifestation of systemic lupus erythematosus (SLE) is cerebral venous sinus thrombosis (CVST), in which early diagnosis and aggressive therapy are of prime importance for favorable outcome. The pathogenesis of CVST is largely unknown, but it is thought to be caused by cerebral vasculitis, antiphospholipid antibodies or other conditions associated with enhanced coagulability. We describe two cases of SLE with CVST which were not associated with antiphospholipid antibodies. Both cases were treated with immunosuppressants (intravenous methylprednisolone and cyclophosphamide pulse therapy) and anticoagulant drugs (heparin and subsequent maintenance therapy with warfarin). There was a marked improvement of neurologic symptoms with the disappearance of thrombus in a follow-up MRI. The possibility of CVST shouldbe considered in any patients with SLE who show neuropsychiatric manifestations.

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Documento generato il 21/09/20 alle ore 15:53:24