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Titolo:
Immunohistochemical analysis of CD44s and CD44v6 in endometriosis and adenomyosis: Comparison with normal, hyperplastic, and malignant endometrium
Autore:
Lin, ZH; Cho, SJ; Jeong, H; Kim, H; Kim, I;
Indirizzi:
Korea Univ, Coll Med, Dept Pathol, Seoul 136701, South Korea Korea Univ Seoul South Korea 136701 pt Pathol, Seoul 136701, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 3, volume: 16, anno: 2001,
pagine: 317 - 322
SICI:
1011-8934(200106)16:3<317:IAOCAC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULES; E-CADHERIN; SPLICE VARIANTS; EXPRESSION; CANCER; CELLS; METASTASES; INTEGRINS; ISOFORMS; TISSUES;
Keywords:
antigens, CD44; endometriosis; endometrial hyperplasia; endometrial neoplasms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, I Korea Univ, Anam Hosp, Dept Pathol, 126-1 5 Ga, Seoul 136705, SouthKorea Korea Univ 126-1 5 Ga Seoul South Korea 136705 136705, South Korea
Citazione:
Z.H. Lin et al., "Immunohistochemical analysis of CD44s and CD44v6 in endometriosis and adenomyosis: Comparison with normal, hyperplastic, and malignant endometrium", J KOR MED S, 16(3), 2001, pp. 317-322

Abstract

The expression patterns of CD44s and CD44v6 were immunohistochemically compared with those of normal, hyperplastic and malignant endometrium. In normal endometria (n=37), endometrioses (n=46) and adenomyoses (n=20), the surface and glandular epithelial cells were negative for CD44s and CD44v6 in a proliferative pattern and positive in a secretory pattern, whereas the stroma was only positive for CD44s in both proliferative and secretory patterns. The endometrial hyperplasia (4 simple and 9 complex) had the identical patterns with normal proliferative phase of endometrium. Only one case showing complex hyperplasia with atypia was focally positive for CD44s and CD44v6in glandular epithelia. CD44s and CD44v6 were positive in all endometrial adenocarcinomas (13), except one CD44s-negative case. In summary, the expressions of CD44s and CD44v6 in endometriosis and adenomyosis recapitulated those of normal cyclic endometrium. The expression patterns in endometrial hyperplasia were similar to those in normal proliferative endometrium, whereas the endometrial adenocarcinoma showed abnormal expressions for CD44s andCD44v6. Thus it was considered that the ectopic endometrium in endometriosis and adenomyosis was not aberrant as in endometrial carcinoma on the aspects of immunohistochemical expressions of CD44s acid CD44v6.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:28:08