Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues
Autore:
Kim, DS; Lee, CB; Park, YS; Ahn, YH; Kim, TW; Kee, CS; Kang, JS; Om, AE;
Indirizzi:
Hanyang Univ, Coll Med, Dept Internal Med, Seoul 133792, South Korea Hanyang Univ Seoul South Korea 133792 nal Med, Seoul 133792, South Korea Hanyang Univ, Coll Med, Dept Pharmacol, Seoul 133791, South Korea Hanyang Univ Seoul South Korea 133791 armacol, Seoul 133791, South Korea Hanyang Univ, Coll Human Ecol, Dept Food & Nutr, Seoul 133791, South KoreaHanyang Univ Seoul South Korea 133791 & Nutr, Seoul 133791, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 3, volume: 16, anno: 2001,
pagine: 313 - 316
SICI:
1011-8934(200106)16:3<313:EOTHOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-PASS-METABOLISM; ETHANOL-METABOLISM; 1ST-PASS METABOLISM; LIVER; KIDNEY; TRIIODOTHYRONINE; INHIBITION; THYROXINE;
Keywords:
alcohol dehydrogenase; thyroid hormones; thyrotoxicosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, DS Hanyang Univ, Coll Med, Dept Internal Med, 17 Haengdang Dong, Seoul 133792, South Korea Hanyang Univ 17 Haengdang Dong Seoul South Korea 133792 uth Korea
Citazione:
D.S. Kim et al., "Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues", J KOR MED S, 16(3), 2001, pp. 313-316

Abstract

The effects of thyroid hormone on hepatic and gastric alcohol dehydrogenase (ADH) activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with thyroxine (1 mg/kg, po) for 14 days. Whereas hepatic ADH activity in thyroxine-treated rats decreasedby 61.3% of control rats (26.4 vs 43.2, p<0.001), gastric ADH activity increased by 262.9% of control rats (4.9 vs 1.9, p<0.001). As for the activities of the lung and kidney, thyroxine treatment did not produce any statistically significant changes. These data suggest that thyrotoxicosis causes a decrease of hepatic alcohol metabolism, and that the increase of gastric ADH activity in thyrotoxic rats can partly restore the first-pass metabolism of ethanol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:14:45