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Titolo:
The steady-state pharmacokinetics of efavirenz and nevirapine when used incombination in human immunodeficiency virus type 1-infected persons
Autore:
Veldkamp, AI; Harris, M; Montaner, JSG; Moyle, G; Gazzard, B; Youle, M; Johnson, M; Kwakkelstein, MO; Carlier, H; van Leeuwen, R; Beijnen, JH; Lange, JMA; Reiss, P; Hoetelmans, RMW;
Indirizzi:
Slotervaart Hosp, Dept Pharm & Pharmacol, NL-1066 EC Amsterdam, Netherlands Slotervaart Hosp Amsterdam Netherlands NL-1066 EC Amsterdam, Netherlands Natl AIDS Therapy Evaluat Ctr, Amsterdam, Netherlands Natl AIDS Therapy Evaluat Ctr Amsterdam Netherlands terdam, Netherlands Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Boehringer Ingelheim, Alkmaar, Netherlands Boehringer Ingelheim Alkmaar Netherlands ngelheim, Alkmaar, Netherlands St Pauls Hosp, Vancouver, BC V6Z 1Y6, Canada St Pauls Hosp Vancouver BC Canada V6Z 1Y6 , Vancouver, BC V6Z 1Y6, Canada Chelsea & Westminster Hosp, London, England Chelsea & Westminster Hosp London England minster Hosp, London, England Royal Free Hosp, London NW3 2QG, England Royal Free Hosp London England NW3 2QG ree Hosp, London NW3 2QG, England Boehringer Ingelheim Int, Brussels, Belgium Boehringer Ingelheim Int Brussels Belgium elheim Int, Brussels, Belgium
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 1, volume: 184, anno: 2001,
pagine: 37 - 42
SICI:
0022-1899(20010701)184:1<37:TSPOEA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ULTRAVIOLET DETECTION; HIV-INFECTION; HUMAN PLASMA; INDINAVIR; LAMIVUDINE; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Veldkamp, AI Slotervaart Hosp, Dept Pharm & Pharmacol, Louwesweg 6, NL-1066 EC Amsterdam, Netherlands Slotervaart Hosp Louwesweg 6 Amsterdam Netherlands NL-1066 EC
Citazione:
A.I. Veldkamp et al., "The steady-state pharmacokinetics of efavirenz and nevirapine when used incombination in human immunodeficiency virus type 1-infected persons", J INFEC DIS, 184(1), 2001, pp. 37-42

Abstract

The steady-state pharmacokinetics of efavirenz and nevirapine, when used in combination to treat human immunodeficiency virus type 1 (HIV-1)-infectedsubjects, were investigated. HIV-1-infected persons who had used efavirenz(600 mg once daily) for greater than or equal to2 weeks were eligible for study inclusion. The plasma pharmacokinetics of efavirenz were determined over 24 h. Subsequently, nevirapine (400 mg once daily) was added to the regimen. After 4 weeks, the pharmacokinetics of efavirenz and nevirapine were assessed over 24 h. The differences between the pharmacokinetic parameters of efavirenz with and without nevirapine were analyzed, and the pharmacokinetics of nevirapine were compared with those in historical control patients. The exposure to efavirenz when combined with nevirapine was significantlydecreased by 22% (area under the plasma concentration vs. time curve), 36%(minimum plasma concentration), and 17% (maximum plasma concentration). Nevirapine pharmacokinetics appear to be unaffected by coadministration of efavirenz, compared with data from historical control patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:02:51